Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study.

Vercellino M; Votta B; Condello C; Piacentino C; Romagnolo A; Merola A; Capello E; Mancardi GL; Mutani R; Giordana MT; Cavalla P

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study.

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Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study.

机译：脉络丛参与多发性硬化症自身免疫性炎症：一项神经病理学研究。

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An immunological function has been proposed for the choroid plexus (CP). In multiple sclerosis (MS) brains, CPs show (immunohistochemistry to HLA-DR, CD3, CD20, CD68, VCAM-1, CD138) T lymphocytes in vessels and stroma, VCAM-1 expression on endothelia, intense HLA-DR immunostaining on cells in CP stroma, among CP epithelium and on epiplexus cells. CPs in control or amyotrophic lateral sclerosis brains do not show such inflammatory changes. Intense CP inflammation is observed in viral encephalitis. Changes in MS CPs suggest persisting immune activation, with intensity similar to acute encephalitis, even in MS phases in which neurodegeneration prevails. In MS, CPs could represent a site for lymphocyte entry in the CSF and for CSF antigens presentation.

机译：已经提出了脉络丛（CP）的免疫功能。在多发性硬化症（MS）大脑中，CP显示（针对HLA-DR，CD3，CD20，CD68，VCAM-1，CD138的免疫组织化学）血管和间质中的T淋巴细胞，内皮细胞上的VCAM-1表达，细胞上强烈的HLA-DR免疫染色在CP基质，CP上皮和上皮细胞中。对照或肌萎缩性侧索硬化脑中的CPs未显示出这种炎症变化。在病毒性脑炎中观察到强烈的CP炎症。 MS CPs的变化表明免疫激活持续存在，强度类似于急性脑炎，即使在发生神经变性的MS阶段也是如此。在MS中，CP可能代表CSF中淋巴细胞进入和CSF抗原呈递的位点。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2008年第2期|共9页
作者
Vercellino M; Votta B; Condello C; Piacentino C; Romagnolo A; Merola A; Capello E; Mancardi GL; Mutani R; Giordana MT; Cavalla P;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
Morphine Sulfate; Ceruloplasmin; Multiple Sclerosis; Inflammation; Choroid Plexus; 血浆铜蓝蛋白; 多发性硬化; 炎症; 脉络丛;

机译：Morphine Sulfate;Ceruloplasmin;Multiple Sclerosis;Inflammation;Choroid Plexus;血浆铜蓝蛋白;多发性硬化;炎症;脉络丛;

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1. Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study. [J] . Vercellino M, Votta B, Condello C, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2008,第1a2期

机译：脉络丛参与多发性硬化症自身免疫性炎症：一项神经病理学研究。
2. Iron Oxide Magnetic Nanoparticles Highlight Early Involvement of the Choroid Plexus in Central Nervous System Inflammation [J] . Jens T. Wuerfel, Susanne Wagner, Carmen Infante-Duarte, Asn Neuro . 2013,第2期

机译：氧化铁磁性纳米颗粒突出脉络膜丛在中枢神经系统炎症中的早期参与
3. Involvement of the choroid plexus in the inflammatory response after acute spinal cord injury in dogs: an immunohistochemical study. [J] . Moore S. A., Oglesbee M. J. Veterinary Immunology and Immunopathology . 2012,第3a4期

机译：犬急性脊髓损伤后脉络丛参与炎症反应的免疫组织化学研究。
4. Effect of Pre-Implantation Factor (PIF)~(*) on Autoimmune Neuroinflammation (Multiple Sclerosis) Using Discovery Proteomics [C] . Ravi Amunugama, Michael J. Ford, Richard C. Jones, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：预注入因子（PIF）〜（*）对使用发现蛋白质组学的自身免疫神经炎（多发性硬化）的影响
5. STAT4 regulates multiple pathogenic mechanisms of CD4 T cells in experimental autoimmune encephalomyelitis, a model of multiple sclerosis [D] . McWilliams, Ian Lee 2015

机译：STAT4调节实验性自身免疫性脑脊髓炎（一种多发性硬化症的模型）中CD4 T细胞的多种致病机制
6. Correction to: Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells [O] . Sabela Rodríguez-Lorenzo, Julia Konings, Susanne van der Pol, 2020

机译：校正至：进行性多发性硬化症中脉络丛发炎：粒细胞和T细胞积聚
7. MRI coupled with clinically-applicable iron oxide nanoparticles reveals choroid plexus involvement in a murine model of neuroinflammation [O] . Violaine Hubert, Chloé Dumot, Elodie Ong, 2019

机译：MRI与临床适用的氧化铁纳米颗粒均显示脉络丛及的神经炎肠道模型

Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study.

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