• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Identification of interleukin-6 producing fibroblastoid cells in cerebrospinal fluid from patients with leukemic meningitis.
【24h】

Identification of interleukin-6 producing fibroblastoid cells in cerebrospinal fluid from patients with leukemic meningitis.

机译：白血病脑膜炎患者脑脊液中产生白介素6的成纤维细胞的鉴定。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cytokine producing native cells in cerebrospinal fluid (CSF) have not been identified. So, we investigated the cytokine producing ability of floating cells in CSF from patients with leukemic meningitis. Morphologic study revealed that established cell lines were polygonal or elongated in shape and had an abundant and irregular branched cytoplasm. Immunocytochemical analysis demonstrated positive reactivity with monoclonal anti-fibroblast antibody only. Interleukin-6 (IL-6) was constitutively produced in vitro by these cell lines; both interleukin-1 and lipopolysaccharides significantly increased its synthesis. These findings imply that these fibroblastoid cells are floating in CSF of patients with leukemic meningitis and produce IL-6 in response to various inflammatory stimulations in vivo.
机译：还没有确定在脑脊髓液（CSF）中产生细胞因子的天然细胞。因此，我们调查了白血病性脑膜炎患者脑脊液中漂浮细胞的细胞因子产生能力。形态学研究显示，已建立的细胞系呈多边形或细长形，并具有丰富且不规则的分支细胞质。免疫细胞化学分析显示仅与单克隆抗成纤维细胞抗体呈阳性反应。这些细胞系在体外组成性地产生白介素6（IL-6）。白介素-1和脂多糖均显着增加其合成。这些发现暗示这些成纤维细胞在白血病性脑膜炎患者的CSF中漂浮，并响应体内各种炎症刺激而产生IL-6。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号