Mutant amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine.

Cao C; Lin X; Zhang C; Wahi MM; Wefes I; Arendash G; Potter H

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Mutant amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine.

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Mutant amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine.

机译：突变的淀粉样β致敏树突状细胞作为阿尔茨海默氏病疫苗。

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Vaccines using bone marrow-derived dendritic cells (DCs) sensitized to Abeta 1-42 peptide and other mutant peptides were tested on BALB/c and APP(SW) transgenic mice. Wild type Abeta 1-42-sensitized DC vaccine (DCSV) produced no response, but all peptides with a T-cell epitope mutation induced antibody responses without inflammation. DCSV with Abeta 1-25 peptide with mutated T-cell epitope failed to induce antibody response, while DCSV with Abeta 1-35 with mutated T-cell epitope produced a strong antibody response. The entire T-cell epitope is required in a DC vaccine to induce antibody response. DCSV with Abeta peptide carrying the entire mutant T-cell epitope may be an appropriate vaccine against AD.

机译：在BALB / c和APP（SW）转基因小鼠上测试了使用对Abeta 1-42肽和其他突变体肽敏感的骨髓来源树突状细胞（DC）的疫苗。野生型Abeta 1-42敏化DC疫苗（DCSV）没有产生反应，但是所有具有T细胞表位突变的肽都可以诱导抗体反应而无炎症。带有突变的T细胞表位的Abeta 1-25肽的DCSV无法诱导抗体反应，而带有突变的T细胞表位的Abeta 1-35的DCSV产生强烈的抗体反应。 DC疫苗需要完整的T细胞表位来诱导抗体反应。带有带有完整突变T细胞表位的Abeta肽的DCSV可能是抗AD的合适疫苗。

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来源
《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2008年第2期|共10页
作者
Cao C; Lin X; Zhang C; Wahi MM; Wefes I; Arendash G; Potter H;
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正文语种 eng
中图分类神经病学与精神病学;医学免疫学;
关键词
Vaccines; T-Lymphocytes; Peptides; Epitopes; Antibodies; 疫苗; T淋巴细胞; 肽类; 表位; 抗体;

机译：Vaccines;T-Lymphocytes;Peptides;Epitopes;Antibodies;疫苗;T淋巴细胞;肽类;表位;抗体;

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1. Mutant amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine. [J] . Cao C, Lin X, Zhang C, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2008,第1a2期

机译：突变的淀粉样β致敏树突状细胞作为阿尔茨海默氏病疫苗。
2. Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells [J] . Fabrice André, Nathalie Chaput, N?el E. C. Schartz, The journal of immunology . 2004,第4期

机译：外来体作为有效的无细胞肽基疫苗。 I.树突状细胞衍生的外来体将功能性MHC I类/肽复合物转移至树突状细胞
3. Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease [J] . Manczak Maria, Kandimalla Ramesh, Yin Xiangling, Human Molecular Genetics . 2018,第8期

机译：海马突变体AP和淀粉样蛋白β诱导的认知性下降，树突脊柱损失，在阿尔茨海默病的小鼠模型中的树突脊柱损失，缺陷的自噬，缺血性和线粒体异常
4. High content image sequence analysis for quantifying calcium signals inside cells with mutant presenilin-1 of familial alzheimer disease [C] . Fuhai Li, Xiaobo Zhou, Jinmin Zhu, IEEE/NIH Life Science Systems and Applications Workshop . 2007

机译：用突变肢体血管疾病突变血浆-1量化细胞内钙信号的高含量图像序列分析
5. Augmenting dendritic cells through pathways that synergize with a HER-2/neu targeted whole-cell tumor vaccine. [D] . Pfannenstiel, Lukas Wyatt. 2009

机译：通过与HER-2 / neu靶向全细胞肿瘤疫苗协同作用的途径增强树突状细胞。
6. Hippocampal mutant APP and amyloid beta-induced cognitive decline dendritic spine loss defective autophagy mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease [O] . Maria Manczak, Ramesh Kandimalla, Xiangling Yin, -1

机译：在阿尔茨海默氏病小鼠模型中海马突变体APP和淀粉样β诱导的认知能力下降树突棘丧失自噬缺陷线粒体和线粒体异常
7. T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine. [O] . Tobias Schwarz, Katharina A Remer, Wiebke Nahrendorf, 2013

机译：T细胞衍生的IL-10决定利什曼病的疾病结果并被基于树突细胞的疫苗抑制。

Mutant amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine.

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