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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism.
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Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism.

机译：针对自闭症儿童的电压依赖性阴离子通道（VDAC）及其保护性配体己糖激酶I的抗体。

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摘要

Autistic children show elevated serum levels of autoantibodies to several proteins essential for the function of normal brains. The voltage-dependent anion channel (VDAC) and hexokinase-I, a VDAC protective ligand, were identified as targets of this autoimmunity in autistic children. These autoantibodies were purified using immunoaffinity chromatographic techniques. Both antibodies induce apoptosis of cultured human neuroblastoma cells. Because VDAC and hexokinase-I are essential for brain protection from ischemic damage, the presence of these autoantibodies suggests a possible causal role in the neurologic pathogenesis of autism.
机译：自闭症儿童显示出针对正常大脑功能所必需的几种蛋白质的自身抗体血清水平升高。电压依赖性阴离子通道（VDAC）和己糖激酶I（一种VDAC保护性配体）被确定为自闭症儿童这种自身免疫的靶标。这些自身抗体使用免疫亲和层析技术纯化。两种抗体均诱导培养的人神经母细胞瘤细胞凋亡。由于VDAC和己糖激酶I对于保护大脑免受缺血性损伤至关重要，因此这些自身抗体的存在表明自闭症的神经系统发病机制可能具有因果作用。

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