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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Identification and characterization of immune complexes in the cerebrospinal fluid of patients with spinal cord schistosomiasis.
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Identification and characterization of immune complexes in the cerebrospinal fluid of patients with spinal cord schistosomiasis.

机译：脊髓血吸虫病患者脑脊液中免疫复合物的鉴定和表征。

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摘要

The pathogenesis of neuroschistosomiasis is largely unknown. Available evidence suggests that it depends on the presence of parasite eggs in the nervous tissue and on the host's immune response. We investigated the presence of immune complexes (ICs) in the cerebrospinal fluid (CSF) of four patients with spinal cord schistosomiasis (SCS), and performed their characterization. ICs containing soluble egg antigen of Schistosoma mansoni (SEA) were found in the CSF of all the SCS patients. To our knowledge, this is the first evidence of ICs containing schistosomal antigens in the CSF of patients with SCS. Further studies are necessary to confirm our findings and investigate the possible roles of ICs in the pathogenesis of this disease.
机译：神经血吸虫病的发病机理在很大程度上是未知的。现有证据表明，这取决于神经组织中寄生虫卵的存在以及宿主的免疫反应。我们调查了四名脊髓型血吸虫病（SCS）患者的脑脊液（CSF）中免疫复合物（ICs）的存在，并进行了表征。在所有SCS患者的CSF中均发现了含有曼氏血吸虫（SEA）可溶性卵抗原的IC。据我们所知，这是SCS患者CSF中含有血吸虫抗原的IC的第一个证据。有必要进行进一步的研究以证实我们的发现并调查ICs在这种疾病的发病机理中的可能作用。

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