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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Elevated plasma C4a levels in multiple sclerosis correlate with disease activity.
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Elevated plasma C4a levels in multiple sclerosis correlate with disease activity.

机译：多发性硬化症中血浆C4a水平升高与疾病活动相关。

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摘要

Complement plays a pivotal role in the pathogenesis of multiple sclerosis. C4a, an activated fragment of complement component C4, has been linked to disease activity. We correlated plasma C4 and plasma and CSF C4a with clinical disease in a well-characterised cohort of patients and controls. Plasma C4 was non-significantly and CSF C4a was significantly elevated overall in patients compared to controls. Plasma C4a was raised only in acute relapse, decreasing over 2 months. Results demonstrate intrathecal and systemic activation of complement, reflected in changes in CSF and plasma C4a. The data support a role for complement activation in pathogenesis and suggest a systemic component to the disease.
机译：补体在多发性硬化症的发病机理中起关键作用。 C4a，补体成分C4的激活片段，已与疾病活动相关。我们将血浆C4和血浆以及脑脊液C4a与临床疾病明确地关联到了患者和对照人群中。与对照组相比，患者的血浆C4无统计学意义，而CSF C4a总体上显着升高。血浆C4a仅在急性复发时升高，并在2个月内降低。结果表明补体鞘内和全身激活，反映在脑脊液和血浆C4a的变化。数据支持补体激活在发病机制中的作用，并提示该疾病的系统性成分。

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