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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >FOXP3+ T regulatory cells in idiopathic inflammatory myopathies.
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FOXP3+ T regulatory cells in idiopathic inflammatory myopathies.

机译：特发性炎症性肌病中的FOXP3 + T调节细胞。

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摘要

FOXP3+ T regulatory cells (Tregs) are considered key players in the maintenance of immune homeostasis. Here we studied the presence and potential role of FOXP3+ Tregs in myositis. CD3 and FOXP3 expression in dermatomyositis, polymyositis and inclusion body myositis was assessed by immunohistochemistry and real-time PCR. FOXP3+ Tregs were found in close proximity to effector cells and their numbers correlated with the degree of inflammation. Despite divergent pathogenetic concepts, we observed no differences in the frequency of FOXP3 immunoreactive cells or FOXP3 mRNA expression between different myositis entities. Functional assays using human myoblasts as targets of CD8+ cells demonstrate that Tregs are capable to inhibit the lytic activity of cytotoxic cells. Our data suggest that FOXP3 Tregs serve to counterbalance muscle destruction by cytotoxic T cells in myositis.
机译：FOXP3 + T调节细胞（Tregs）被认为是维持免疫稳态的关键因素。在这里，我们研究了FOXP3 + Treg在肌炎中的存在及其潜在作用。通过免疫组织化学和实时荧光定量PCR检测皮肌炎，多发性肌炎和包涵体肌炎中CD3和FOXP3的表达。发现FOXP3 + Treg与效应细胞非常接近，其数量与炎症程度相关。尽管有不同的病原学概念，我们观察到不同肌炎实体之间的FOXP3免疫反应细胞或FOXP3 mRNA表达的频率没有差异。使用人成肌细胞作为CD8 +细胞靶标的功能分析表明，Tregs能够抑制细胞毒性细胞的裂解活性。我们的数据表明，FOXP3 Treg可抵消肌炎中细胞毒性T细胞对肌肉的破坏。

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