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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Exogenous granulocyte colony-stimulating factor exacerbate pain-related behaviors after peripheral nerve injury.
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Exogenous granulocyte colony-stimulating factor exacerbate pain-related behaviors after peripheral nerve injury.

机译：外源粒细胞集落刺激因子加重周围神经损伤后疼痛相关的行为。

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摘要

Previous studies have demonstrated that inflammatory cells produce several mediators that can effectively counteract pain. This study was designed to test the hypothesis that exogenous administration of recombinant mouse granulocyte-colony-stimulating factor (rmG-CSF) to enhance the recruitment of inflammatory cells to painful inflamed sites could attenuate pain in a chronic neuropathic pain model in mice. Our results indicate that treatment with rmG-CSF increased several cytokines and opioid peptides content; however, it did not attenuate but exacerbate neuropathic pain. Our study highlights the potent pro-inflammatory potential of G-CSF and suggests they may be targets for therapeutic intervention in chronic neuropathic pain.
机译：先前的研究表明，炎症细胞会产生几种可以有效抵抗疼痛的介质。这项研究旨在验证以下假设：外源给予重组小鼠粒细胞集落刺激因子（rmG-CSF）以增强炎症细胞向疼痛发炎部位的募集可以减轻小鼠慢性神经性疼痛模型中的疼痛。我们的结果表明，用rmG-CSF治疗可增加几种细胞因子和阿片类肽的含量。然而，它并没有减轻但加剧了神经性疼痛。我们的研究突出了G-CSF的潜在促炎潜力，并暗示它们可能是慢性神经性疼痛的治疗干预目标。

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