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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Muscle-specific kinase antibody positive myaesthenia gravis and multiple sclerosis co-presentation: A case report and literature review
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Muscle-specific kinase antibody positive myaesthenia gravis and multiple sclerosis co-presentation: A case report and literature review

机译：肌肉特异性激酶抗体阳性重症肌无力和多发性硬化症的共同表现：一例病例报告并文献复习

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摘要

We present the first case of simultaneous muscle-specific kinase antibody positive myaesthenia gravis and relapsing-remitting multiple sclerosis to be reported in the English literature along with the inherent diagnostic and treatment challenges. There may be an association between myaesthenia and central nervous system demyelination. We identified 72 previously published cases of myaesthenia with central nervous system demyelination. Of 19 cases of myaesthenia with relapsing-remitting multiple sclerosis, nine (47%) were acetylcholine receptor antibody negative, but there were no previously published cases with muscle-specific kinase antibody. Further research is required to clarify this association and optimal treatment in such cases.
机译：我们介绍了第一例同时发生的肌肉特异性激酶抗体阳性的重症肌无力和复发缓解型多发性硬化症，这在英国文学中已有报道，同时也面临固有的诊断和治疗挑战。肌无力和中枢神经系统脱髓鞘之间可能存在关联。我们确定了72例先前发表的中枢神经系统脱髓鞘性肌无力病例。在19例患有复发缓解型多发性硬化症的肌无力患者中，有9例（47％）的乙酰胆碱受体抗体阴性，但以前没有发表过肌肉特异性激酶抗体的病例。在这种情况下，需要进一步研究以阐明这种关联和最佳治疗方法。

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