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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >IVIG regulates BAFF expression in patients with chronic inflammatory demyelinating polyneuropathy (CIDP)
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IVIG regulates BAFF expression in patients with chronic inflammatory demyelinating polyneuropathy (CIDP)

机译：IVIG调节慢性炎症性脱髓鞘性多发性神经病（CIDP）患者的BAFF表达

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摘要

Recent studies indicate that the cytokine B-cell activating factor (BAFF) is involved in the pathogenesis of chronic inflammatory demyelinating polyneuropathy (CIDP). Intravenous immunoglobulin (IVIg) is standard treatment for CIDP and is known to rapidly modulate increased serum levels of pro-inflammatory cytokines. We evaluated the expression profile of BAFF and its corresponding BAFF-receptor in samples from CIDP patients, focusing on rapid changes before and after IVIg treatment In CIDP patients BAFF serum concentrations were elevated compared to controls. Treatment with high-dose IVIg restored those elevated BAFF serum levels. Whereas treatment with IVIg did not affect BAFF production in monocytes, antibodies against BAFF could be detected in IVIg preparations, which may explain the short-term decrease of BAFF levels after IVIg treatment. Our data suggest that BAFF plays an important role in the pathogenesis of CIDP and may serve as marker for IVIg treatment response.
机译：最近的研究表明，细胞因子B细胞活化因子（BAFF）参与慢性炎性脱髓鞘性多发性神经病（CIDP）的发病机理。静脉免疫球蛋白（IVIg）是CIDP的标准治疗方法，已知可以迅速调节血清中促炎性细胞因子的水平。我们评估了CIDP患者样品中BAFF及其相应BAFF受体的表达谱，重点研究了IVIg治疗前后的快速变化。在CIDP患者中，与对照组相比，BAFF血清浓度升高。用大剂量IVIg治疗可恢复那些升高的BAFF血清水平。尽管用IVIg治疗不会影响单核细胞中BAFF的产生，但是在IVIg制剂中可以检测到针对BAFF的抗体，这可以解释IVIg治疗后BAFF水平的短期下降。我们的数据表明，BAFF在CIDP的发病机理中起着重要的作用，并且可以作为IVIg治疗反应的标志。

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