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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia
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Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia

机译：重症肌无力胸腺增生患者Hassall球体数量增加

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摘要

The thymus is implicated as an organ that contributes to autoimmunity in myasthenia gravis (MG) patients. Hassall's corpuscles (HCs) are assumed to represent the terminally differentiated stage of medullary thymic epithelial cells (mTECs). By using multicolor immunohistofluorescence analysis, we examined HCs in thymuses that were therapeutically excised from MG (+) and MG (-) patients. We found that the number of HCs per unit area of the thymic medulla was significantly elevated in the thymuses of MG (+) patients with thymic hyperplasia. CCL21 expression increased in the hyperplastic MG thymuses. We speculate that the altered differentiation of mTECs is associated with the thymic hyperplasia and the onset of MG.
机译：胸腺牵涉为重症肌无力（MG）患者自身免疫的器官。假设Hassall的小体（HCs）代表了髓样胸腺上皮细胞（mTECs）的终末分化阶段。通过使用多色免疫组织荧光分析，我们检查了从MG（+）和MG（-）患者治疗切除的胸腺中的HCs。我们发现，在患有胸腺增生的MG（+）患者的胸腺中，胸腺髓质单位面积的HCs数量显着增加。在增生的MG胸腺中CCL21表达增加。我们推测，mTECs的分化改变与胸腺增生和MG的发作有关。

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