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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Corticosteroid receptor expression and in vivo glucocorticoid sensitivity in multiple sclerosis
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Corticosteroid receptor expression and in vivo glucocorticoid sensitivity in multiple sclerosis

机译：多发性硬化症中糖皮质激素受体的表达和体内糖皮质激素敏感性

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摘要

To estimate the efficiency of glucocorticoid signaling in multiple sclerosis in vivo, we measured mRNA expression of glucocorticoid receptor (GR), mineralocorticoid receptor (MR) and four genes regulated by GR and implicated in immune function, in whole blood. GR expression and MR expression were significantly lower in 52 patients than in 18 controls. In contrast, expression of GR regulated genes was increased (significantly for glucocorticoid induced leucine zipper, GILZ), especially in mildly impaired patients. Reduced GR expression appears to be compensated, either by hyperactive hypothalamo-pituitary-adrenal axis or by intracellular adaptations.
机译：为了评估糖皮质激素信号传导在体内多发性硬化中的效率，我们在全血中测量了糖皮质激素受体（GR），盐皮质激素受体（MR）和受GR调节并涉及免疫功能的四个基因的mRNA表达。 52例患者的GR表达和MR表达明显低于18例对照。相反，GR调节基因的表达增加（对于糖皮质激素诱导的亮氨酸拉链，GILZ显着增加），尤其是在轻度受损的患者中。降低的GR表达似乎被下丘脑-垂体-肾上腺轴过动或细胞内适应所补偿。

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