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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Neonatal Escherichia coli K1 meningitis causes learning and memory impairments in adulthood
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Neonatal Escherichia coli K1 meningitis causes learning and memory impairments in adulthood

机译：新生儿大肠杆菌K1脑膜炎导致成年后的学习和记忆障碍

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摘要

Neonatal Escherichia coli meningitis continues to be an important cause of mortality and morbidity in newborns worldwide. The aim of this study was to investigate the cytokines/chemokines, brain-derived neurotrophic factor (BDNF) levels, blood-brain barrier integrity in neonatal rats following E. coli K1 experimental meningitis infection and subsequent behavioural parameters in adulthood. In the hippocampus, interleukin increased at 96. h, IL-6 at 12, 48 and 96. h, IL-10 at 96. h, cytokine-induced neutrophil chemoattractant-1 at 6, 12, 24, 48 and 96. h, and BDNF at 48 and 96. h. In the cerebrospinal fluid, tumour necrosis factor alpha levels increased at 6, 12, 24, 48 and 96. h. The BBB breakdown occurred at 12. h in the hippocampus, and at 6. h in the cortex. We evaluated behavioural parameters in adulthood: habituation to the open-field, step-down inhibitory avoidance, object recognition, continuous multiple-trials step-down inhibitory avoidance and forced swimming tasks. In adulthood, the animals showed habituation and aversive memory impairment. The animals needed a significant increase in the number of training periods to learn and not had depressive-like symptoms.
机译：新生儿大肠杆菌性脑膜炎仍然是全世界新生儿死亡和发病的重要原因。这项研究的目的是调查大肠杆菌K1实验性脑膜炎感染后新生大鼠的细胞因子/趋化因子，脑源性神经营养因子（BDNF）水平，血脑屏障完整性以及成年后的行为参数。在海马中，白细胞介素在96.h升高，IL-6在12、48和96.h，IL-10在96.h升高，细胞因子诱导的中性粒细胞趋化因子-1在6、12、24、48和96.h升高。和BDNF分别在48和96。在脑脊液中，肿瘤坏死因子α水平在6、12、24、48和96 h升高。 BBB分解发生在海马区的12. h和皮层的6. h。我们评估了成年后的行为参数：适应野外的习惯，避免下台抑制，物体识别，连续多次尝试的下架抑制避开和强迫游泳。在成年期，这些动物表现出习惯性和厌恶性记忆障碍。这些动物需要大量训练才能学习，并且没有抑郁症样症状。

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