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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Long-distance effects of inflammation on differentiation of adult spinal cord neural stem/progenitor cells
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Long-distance effects of inflammation on differentiation of adult spinal cord neural stem/progenitor cells

机译：炎症对成年脊髓神经干/祖细胞分化的远距离影响

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Studies in multiple sclerosis have demonstrated that normal-appearing white matter can harbor pathological changes. Here we investigated the effects of neuroinflammation, modeled by experimental autoimmune encephalomyelitis (EAE) on neural stem/progenitor cells (NPCs) located distally to inflammatory foci. We observed that EAE-derived NPCs had a lower capacity to differentiate into oligodendrocytes and an increased neuronal differentiation than control NPCs. This finding was corroborated with changes in gene expression of early differentiation genes. We conclude that inflammation has a long range effect on the NPCs in the diseased central nervous system, reaching NPC populations outside the lesion sites. (C) 2015 The Authors. Published by Elsevier B.V.
机译：对多发性硬化症的研究表明，正常出现的白质可能具有病理变化。在这里，我们研究了以实验性自身免疫性脑脊髓炎（EAE）为模型的神经炎症对位于炎性灶远端的神经干/祖细胞（NPC）的影响。我们观察到，与对照NPC相比，EAE衍生的NPC分化为少突胶质细胞的能力较低，神经元分化程度更高。早期分化基因的基因表达变化证实了这一发现。我们得出的结论是，炎症对患病的中枢神经系统中的NPC具有长远的影响，到达病变部位以外的NPC人群。 （C）2015作者。由Elsevier B.V.发布

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