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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Plasmacytosis is a common immune signature in patients with MMN and CIDP and responds to treatment with IVIg
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Plasmacytosis is a common immune signature in patients with MMN and CIDP and responds to treatment with IVIg

机译：浆细胞增多症是MMN和CIDP患者的常见免疫特征，对IVIg治疗有反应

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摘要

B cells and antibodies are thought to be relevant in chronic immune neuropathies (ON). We analysed peripheral B-cell homeostasis and effects of high-dose intravenous immunoglobulin (IVIg) on B-cell phenotypes in patients with multifocal motor neuropathy (n = 22) and chronic inflammatory demyelinating polyneuropathy (n = 8) by multi-color flow cytometry. At baseline, total B-cell numbers were decreased, but mature plasma cells were markedly elevated. IVIg rapidly prompted a decrease in plasma cell numbers and left B-cell homeostasis unchanged. Thus, expanded frequencies of plasma cells might be involved in CIN immunopathogenesis and are downscaled after clinically successful Mg administration. (C) 2014 Elsevier B.V. All rights reserved.
机译：B细胞和抗体被认为与慢性免疫神经病（ON）有关。我们通过多色流式细胞术分析了多灶性运动神经病（n = 22）和慢性炎性脱髓鞘性多发性神经病（n = 8）患者的外周血B细胞稳态和大剂量静脉内免疫球蛋白（IVIg）对B细胞表型的影响。基线时，总B细胞数量减少，但成熟浆细胞明显升高。 IVIg迅速促使血浆细胞数量减少，并使B细胞稳态保持不变。因此，浆细胞的扩展频率可能参与CIN免疫发病机制，并在临床上成功施用Mg后降低了比例。 （C）2014 Elsevier B.V.保留所有权利。

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