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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Association of circulating follicular helper T cells with disease course of NMO spectrum disorders
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Association of circulating follicular helper T cells with disease course of NMO spectrum disorders

机译：循环滤泡辅助性T细胞与NMO频谱疾病病程的关系

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摘要

While follicular helper T (Tfh) cells have been shown to be involved in many autoimmune diseases, the association of Tfh cells with the disease activity of neuromyelitis optica spectrum disorders (NMOSDs) remains unclear. In this study, the CD4(+)CXCR5(+)PD-1(+)Tfh cell population in peripheral blood mononuclear cells (PBMCs) obtained from NMOSD patients, age- and gender-matched healthy controls, and multiple sclerosis patients was compared by flow cytometry. The serum levels of IL-21, IL-6, IL-17, TNF-alpha and IL-10 were analyzed by ELISA assays. We found that in NMOSD, the Tfh cell frequency is higher than that of healthy subjects and multiple sclerosis (MS) patients. There are more Tfh cells in the relapsing stage than the remitting stage of NMOSD, thus demonstrating the close association of the Tfh cell population with disease activity. Methylprednisolone, which is used to control disease relapses, significantly decreased the proportion of Tfh cells in NMOSD patients. (C) 2014 Elsevier B.V. All rights reserved.
机译：尽管卵泡辅助性T（Tfh）细胞已显示出参与许多自身免疫性疾病，但Tfh细胞与视神经脊髓炎光谱疾病（NMOSDs）的疾病活动性之间的关联仍不清楚。在这项研究中，比较了从NMOSD患者，年龄和性别匹配的健康对照以及多发性硬化症患者获得的外周血单个核细胞（PBMC）中的CD4（+）CXCR5（+）PD-1（+）Tfh细胞数量通过流式细胞仪。通过ELISA测定分析了IL-21，IL-6，IL-17，TNF-α和IL-10的血清水平。我们发现，在NMOSD中，Tfh细胞频率高于健康受试者和多发性硬化症（MS）患者。复发期的Tfh细胞多于NMOSD的复发期，因此证明Tfh细胞群与疾病活动密切相关。用于控制疾病复发的甲基强的松龙可显着降低NMOSD患者中Tfh细胞的比例。 （C）2014 Elsevier B.V.保留所有权利。

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