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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Smoking worsens multiple sclerosis prognosis: Two different pathways are involved
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Smoking worsens multiple sclerosis prognosis: Two different pathways are involved

机译：吸烟会使多发性硬化症的预后恶化：涉及两种不同的途径

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摘要

Smoking worsens multiple sclerosis (MS) prognosis. Our study provides evidence that indoleamine 2,3-dioxygenase activity is reduced in MS patients who smoke, leading to increased production of IL-6 and IL-13. Additionally, both degree of expression and renin-angiotensin system activity levels were increased in MS patients who smoked, inducing increase in IL-17 and IL-22-producing cell numbers as well as significantly greater production of CCL2, CCL3 and CXCL10 chemokines by monocytes. Finally, both pathways contributed to a significant decrease in the number of CD4+CD25+FoxP3 + regulatory T cells in MS patients who smoked. Both pathways could be responsible for the association between smoking and MS risk. (C) 2015 Elsevier B.V. All rights reserved.
机译：吸烟会使多发性硬化（MS）的预后恶化。我们的研究提供证据表明，吸烟的MS患者的吲哚胺2,3-二加氧酶活性降低，从而导致IL-6和IL-13的产生增加。此外，吸烟的MS患者的表达程度和肾素-血管紧张素系统活性水平均增加，导致IL-17和IL-22产生细胞数量增加，单核细胞产生的CCL2，CCL3和CXCL10趋化因子明显增加。 。最后，这两种途径均导致吸烟的MS患者的CD4 + CD25 + FoxP3 +调节性T细胞数量显着减少。两种途径都可能导致吸烟与MS风险之间的相关性。 （C）2015 Elsevier B.V.保留所有权利。

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