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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Disruption of estrous cycle homeostasis in mice with experimental autoimmune encephalomyelitis
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Disruption of estrous cycle homeostasis in mice with experimental autoimmune encephalomyelitis

机译：实验性自身免疫性脑脊髓炎小鼠发情周期稳态的破坏

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摘要

Multiple sclerosis (MS) is widely viewed as a prototypic human autoimmune disease involving proinflammatory T cells that induce lesions in the central nervous system (CNS) in response to myelin self proteins. Although the impact of sex hormones on MS is well recognized, the converse effects of autoimmunity on sex hormones are still unclear. The current study was designed to assess the impact of CNS autoimmunity on female reproductive physiology. In order to identify subtle hormonal disturbances as a result of autoimmunity, we analyzed the estrous cycle in SJL/J mice after active induction of experimental autoimmune encephalomyelitis (EAE), an animal model with substantial similarities to MS. Here we show that CNS autoimmunity significantly shortens the murine estrous cycle. This shortening of the estrous cycle is characterized by a dramatic decrease in the length of the metestrus-diestrus luteal phase partially offset by a highly significant but less dramatic elongation of the proestrus-estrus follicular phase of the uterine cycle. Thus, our study provides experimental evidence for a direct causal link between CNS autoimmunity and disruption of the homeostatic balance of the uterine cycle often observed in women with MS. (C) 2015 Elsevier B.V. All rights reserved.
机译：多发性硬化症（MS）被广泛认为是一种原型人类自身免疫性疾病，涉及促炎性T细胞，可对髓鞘自身蛋白作出反应，诱导中枢神经系统（CNS）的病变。尽管人们普遍认识到性激素对MS的影响，但自身免疫对性激素的相反影响仍不清楚。当前的研究旨在评估中枢神经系统自身免疫对女性生殖生理的影响。为了鉴定由于自身免疫引起的细微激素紊乱，我们在主动诱导实验性自身免疫性脑脊髓炎（EAE）后，对SJL / J小鼠的发情周期进行了分析。在这里，我们表明中枢神经系统自身免疫性显着缩短了小鼠发情周期。发情周期的缩短的特征在于，子宫周期的发情-发情卵泡期的高度显着但不那么戏剧性的延伸抵消了部分的子宫-二黄体黄体期长度的急剧减少。因此，我们的研究为中枢神经系统自身免疫与经常在多发性硬化症女性中观察到的子宫周期内稳态平衡破坏之间的直接因果关系提供了实验证据。 （C）2015 Elsevier B.V.保留所有权利。

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