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首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Increased natural killer cell chemotaxis to CXCL12 in patients with multiple sclerosis
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Increased natural killer cell chemotaxis to CXCL12 in patients with multiple sclerosis

机译：多发性硬化症患者对CXCL12的自然杀伤细胞趋化性增加

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摘要

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease characterized by leukocyte infiltration into the central nervous system (CNS). Migration of lymphocyte subpopulations towards CXCL12 was analyzed coupled to six-color flow cytometry in untreated patients in the remitting phase, during relapse, in patients with clinically isolated syndrome (CIS), and in healthy volunteers. Significantly higher migration rates of natural killer cells (CD45+CD3-CD16/56+) were observed in patients in remission and CIS patients than in patients during relapse and in controls. Moreover, the frequency of CD3-CD16/56+CXCR4+ cells is higher in patients in remission and in CIS patients, but not during relapse. (C) 2015 Elsevier B.V. All rights reserved.
机译：多发性硬化症（MS）是一种炎症性和神经退行性疾病，其特征在于白细胞浸润到中枢神经系统（CNS）中。在未治疗的患者中，在缓解期，复发期间，临床孤立综合征（CIS）患者和健康志愿者中，分析了淋巴细胞亚群向CXCL12的迁移与六色流式细胞仪的结合。缓解期和CIS患者中观察到的自然杀伤细胞（CD45 + CD3-CD16 / 56 +）迁移率明显高于复发期间和对照患者。此外，缓解期患者和CIS患者中CD3-CD16 / 56 + CXCR4 +细胞的频率较高，但复发期间则不。 （C）2015 Elsevier B.V.保留所有权利。

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