首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >A clinical and laboratory study evaluating the profile of cytokine levels in relapsing remitting and secondary progressive multiple sclerosis
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A clinical and laboratory study evaluating the profile of cytokine levels in relapsing remitting and secondary progressive multiple sclerosis

机译:临床和实验室研究评估复发缓解和继发进行性多发性硬化症中细胞因子水平的概况

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摘要

The main aim of the study was to evaluate levels of cytokines IL-1ra, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, TNF-alfa, TGB-beta1 and IFN-gamma in 30 patients with relapsing remitting (RRMS) compared to 30 secondary progressive multiple sclerosis (SPMS) in a peripheral blood sample. Statistical analysis showed significant higher levels of IL-17 and INF-gamma, which are cytokines with pro-inflammatory properties, and lower levels of TGF-beta1, a molecule with immunosuppressant activity, in RRMS compared to SPMS. These results underline the existence of a different cytokines dysregulation in RRMS compared to SPMS phases with higher proinflammatory activity in RRMS. (C) 2014 Published by Elsevier B.V.
机译:该研究的主要目的是评估细胞因子IL-1ra,IL-2,IL-4,IL-6,IL-8,IL-10,IL-12,IL-17,TNF-α,TGB-外周血样本中30例复发缓解(RRMS)患者中的beta1和IFN-γ与30例继发进行性多发性硬化症(SPMS)相比。统计分析显示,与SPMS相比,RRMS中具有促炎特性的细胞因子IL-17和INF-γ明显较高,而具有免疫抑制活性的分子TGF-beta1则较低。这些结果表明,与RRMS中具有较高促炎活性的SPMS阶段相比,RRMS中存在不同的细胞因子失调。 (C)2014由Elsevier B.V.发布

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