The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.

Huang XN; Fu J; Wang WZ

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.

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The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.

机译：法舒地尔对实验性自身免疫性脑脊髓炎后大鼠血脑屏障和血脊髓屏障通透性的影响。

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Dysfunction of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) is a primary characteristic of multiple sclerosis (MS). We evaluated the protective effects of fasudil, a selective ROCK inhibitor, in a model of experimental autoimmune encephalomyelitis (EAE) that was induced by guinea-pig spinal cord. In addition, we studied the effects of fasudil on BBB and BSCB permeability. We found that fasudil partly alleviated EAE-dependent damage by decreasing BBB and BSCB permeability. These results provide rationale for the development of selective inhibitors of Rho kinase as a novel therapy for MS.

机译：血脑屏障（BBB）和血脊髓屏障（BSCB）的功能障碍是多发性硬化症（MS）的主要特征。我们在豚鼠脊髓诱发的实验性自身免疫性脑脊髓炎（EAE）模型中评估了选择性ROCK抑制剂法舒地尔的保护作用。此外，我们研究了法舒地尔对BBB和BSCB渗透性的影响。我们发现法舒地尔通过降低BBB和BSCB通透性部分缓解了EAE依赖性损害。这些结果为开发Rho激酶选择性抑制剂作为MS的新疗法提供了理论依据。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2011年第2期|共7页
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Huang XN; Fu J; Wang WZ;
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中图分类神经病学;
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1. The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis. [J] . Huang XN, Fu J, Wang WZ Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2011,第1a2期

机译：法舒地尔对实验性自身免疫性脑脊髓炎后大鼠血脑屏障和血脊髓屏障通透性的影响。
2. Comparison of the timing of acute blood-brain barrier breakdown to rabbit immunoglobulin G in the cerebellum and spinal cord of mice with experimental autoimmune encephalomyelitis. [J] . Tonra JR, Reiseter BS, Kolbeck R, The Journal of Comparative Neurology . 2001,第1期

机译：实验性自身免疫性脑脊髓炎小鼠小脑和脊髓中急性血脑屏障破坏与兔免疫球蛋白G的时机比较。
3. Effect of spinal cord injury on the permeability of the blood-brain and blood-spinal cord barriers to the neurotropin PACAP. [J] . Banks WA, Kastin AJ, Arimura A Experimental Neurology . 1998,第1期

机译：脊髓损伤对神经营养蛋白PACAP的血脑和脊髓屏障渗透性的影响。
4. In vivo imaging of blood-spinal cord barrier permeability with dynamic contrast enhanced MRI of spinal cord injury [C] . Bilgen, M., Dogan, . 2002

机译：动态对比增强对脊髓损伤的MRI显示的血脊髓屏障通透性的体内成像
5. Blood-Spinal Cord Barrier Dysfunction in Neurodegeneration. [D] . Winkler, Ethan A. 2012

机译：神经变性中的血脊髓屏障功能障碍。
6. Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier [O] . P Marc D Watson, Judy C Paterson, George Thom, 2013

机译：建模内皮血液中枢神经系统屏障：一种产生大鼠血脑屏障和血脊髓屏障的强大体外模型的方法
7. Modelling the endothelial blood-CNS barriers: a method for the production of robust models of the rat blood-brain barrier and blood-spinal cord barrier [O] . 2013

机译：建模内皮细胞中枢神经系统屏障：一种用于生成大鼠血脑屏障和血脊髓屏障的鲁棒模型的方法

The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.

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