Determination of kFLC and K index in cerebrospinal fluid: A valid alternative to assessintrathecal immunoglobulin synthesis

DurantiF.; PieriM.; CentonzeD.; ButtariF.; BernardiniS.; DessiM.

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Determination of kFLC and K index in cerebrospinal fluid: A valid alternative to assessintrathecal immunoglobulin synthesis

机译：脑脊液中kFLC和K指数的测定：评估鞘内免疫球蛋白合成的有效替代方法

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Intrathecal immunoglobulin synthesis is observed in several disorders of the central nervous system, but its detection by current laboratory tests is relatively insensitive and operator depending. We assessed the diagnostic accuracy of a nephelometric assay for k free light chain determination in cerebrospinal fluid and serum. The patients were grouped according to clinical and laboratory criteria. ROC curves for all methods were performed to find the best cut-off value. kFLC Index seems to be more accurate than other parameters. Our data indicate that nephelometric assay for kFLCs in CSF reliably detect intrathecal immunoglobulin synthesis and discriminate multiple sclerosis patients.

机译：鞘内免疫球蛋白的合成在中枢神经系统的几种疾病中都可以观察到，但是目前实验室检测的鞘内免疫球蛋白合成相对不灵敏并且取决于操作者。我们评估了浊度测定法对脑脊液和血清中k游离轻链测定的诊断准确性。根据临床和实验室标准将患者分组。执行所有方法的ROC曲线以找到最佳的临界值。 kFLC指数似乎比其他参数更准确。我们的数据表明，对CSF中的kFLC进行比浊法测定能够可靠地检测鞘内免疫球蛋白的合成并区分多发性硬化症患者。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2013年第2期|共5页
作者
DurantiF.; PieriM.; CentonzeD.; ButtariF.; BernardiniS.; DessiM.;
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正文语种 eng
中图分类神经病学;
关键词
CSF; KFLC Index; KFLCs; Multiple sclerosis; Nephelometry; OCBs;

机译：脑脊液;KFLC指数;KFLCs;多发性硬化;浊度法;OCBs;

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1. Determination of kFLC and K index in cerebrospinal fluid: A valid alternative to assessintrathecal immunoglobulin synthesis [J] . DurantiF., PieriM., CentonzeD., Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2013,第1a2期

机译：脑脊液中kFLC和K指数的测定：评估鞘内免疫球蛋白合成的有效替代方法
2. Criteria for the diagnosis of neurosyphilis in cerebrospinal fluid: Relationships with intrathecal immunoglobulin synthesis and blood-cerebrospinal fluid barrier dysfunction [J] . LevchikN., PonomarevaM., SurganovaV., Sexually transmitted diseases . 2013,第12期

机译：脑脊髓液中神经孢子诊断的标准：与鞘内免疫球蛋白合成和血液脑脊液屏障功能障碍的关系
3. Evaluation of a microsphere-based immunofluorescence assay for the determination of Immunoglobulin A concentrations in cerebrospinal fluid of dogs. [J] . Roerig A., Carlson R., Tipold A. Research in Veterinary Science . 2013,第1期

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4. Using Single-walled Carbon Nanotubes as Solid-phase Extraction Adsorbent for the Sensitive Determination of Amino Acid Neurotransmitters in Human Cerebrospinal Fluids [C] . ZHANG Xiaoling, YANG Qiao International Conference on Micro Nano Devices, Structure and Computing Systems . 2011

机译：用单壁碳纳米管作为固相萃取吸附剂，用于敏感的氨基酸神经递质在人脑脊液中的敏感测定
5. Towards multidimensional separations of cerebrospinal fluid proteins in microfluidic devices. [D] . Li, Chen. 2005

机译：迈向微流体装置中脑脊液蛋白质的多维分离。
6. A new method for determination of varicella-zoster virus immunoglobulin G avidity in serum and cerebrospinal fluid [O] . Ralf-Herbert Kneitz, Jörg Schubert, Franz Tollmann, 2004

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7. A new method for determination of varicella-zoster virus immunoglobulin G avidity in serum and cerebrospinal fluid [O] . Ralf-Herbert Kneitz, Jörg Schubert, Franz Tollmann, 2004

机译：测定血清和脑脊髓液中水痘带状疱疹病毒免疫球蛋白G亲和力的新方法
8. Antibody Capture Immunoassay Detection of Japanese Encephalitis Virus Immunoglobulin M and G Antibodies in Cerebrospinal Fluid [R] . Burke, D. S., Nisalak, A., Ussery, M. A. 1982

机译：抗体捕获免疫分析检测脑脊液中流行性乙型脑炎病毒免疫球蛋白m和G抗体

Determination of kFLC and K index in cerebrospinal fluid: A valid alternative to assessintrathecal immunoglobulin synthesis

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