Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes

DeJongsteA.H.C.; DeGraafM.T.; VandenBroekP.D.M.; KraanJ.; SillevisSmittP.A.E.; GratamaJ.W.

首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes

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Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes

机译：抗Hu抗体相关的副肿瘤性神经系统综合症患者脑脊液中调节性T细胞，中央记忆T细胞和类转换B细胞数量增加

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Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and other inflammatory central nervous system disorders.

机译：多参数流式细胞术用于研究11例新诊断为进行性抗Hu抗体相关副肿瘤性神经综合征（Hu-PNS），9例其他炎性神经系统疾病（IND）的成对血液和CSF样本中的淋巴细胞亚群和树突状细胞）和其他非炎性神经系统疾病（OND）的12例患者。 Hu-PNS患者的CSF中调节性T细胞，中枢记忆T细胞，类转换B细胞和树突状细胞数量增加。这些发现支持了免疫系统在Hu-PNS中局部激活的假说，并暗示了Hu-PNS与其他炎症性中枢神经系统疾病之间的常见病因学途径。

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《Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology》 |2013年第2期|共6页
作者
DeJongsteA.H.C.; DeGraafM.T.; VandenBroekP.D.M.; KraanJ.; SillevisSmittP.A.E.; GratamaJ.W.;
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正文语种 eng
中图分类神经病学;
关键词
B cells; Central memory T cells; Cerebrospinal fluid; Hu-antibody; Paraneoplastic neurological syndromes; Regulatory T cells;

机译：B细胞;中央记忆T细胞;脑脊液;Hu抗体;副肿瘤神经综合征;调节性T细胞;

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1. Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes [J] . DeJongsteA.H.C., DeGraafM.T., VandenBroekP.D.M., Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2013,第1a2期

机译：抗Hu抗体相关的副肿瘤性神经系统综合症患者脑脊液中调节性T细胞，中央记忆T细胞和类转换B细胞数量增加
2. Three sensitive assays do not provide evidence for circulating HuD-specific T cells in the blood of patients with paraneoplastic neurological syndromes with anti-Hu antibodies [J] . Adriaan H.C. de Jongste, Marieke T. de Graaf, Emanuela Martinuzzi, Neuro-Oncology . 2012,第7期

机译：三种敏感的测定方法均未提供证据证明抗Hu抗体的副肿瘤性神经系统综合征患者血液中的HuD特异性T细胞循环
3. No evidence for the presence of HuD-specific T cells in the cerebrospinal fluid of patients with Huassociated paraneoplastic neurological syndromes. [J] . de-Beukelaar JW, Milikan JC, Verjans GM, Journal of neurology . 2009,第2期

机译：没有证据表明Huassociated副肿瘤性神经系统综合症患者的脑脊液中存在HuD特异性T细胞。
4. Expression of CD4+CD25+ T regulatory cells and Foxp3 in peripheral blood of patients with Rheumatoid Arthritis Patient [C] . Kexin Sun, Yan Li, Suhong Guo, International Conference on Applied Science, Engineering and Technology . 2013

机译：类风湿性关节炎患者外周血CD4 + CD25 + T调节细胞和FOXP3的表达
5. B Cell Toll-Like Receptor/B Cell Receptor Co-Engagement Induces Hypermutated and Class-Switched Protective Antibody Responses in the Absence of T Cells [D] . Rivera, Carlos Eduardo. 2020

机译：B细胞的Toll样受体/ B细胞受体共接合在不存在T细胞的情况下诱导超矫正和类切换的保护抗体反应
6. Proliferative response of peripheral blood mononuclear cells in anti-Hu antibody-associated patients with paraneoplastic neurological syndrome and their depressant effect on small cell lung cancer cells [O] . LIANG YIN, HONGDANG QU, QIMING CHEN -1

机译：抗Hu抗体相关的副肿瘤神经综合征患者外周血单个核细胞的增殖反应及其对小细胞肺癌细胞的抑制作用
7. Rare Association of Anti-Hu Antibody Positive Paraneoplastic Neurological Syndrome and Transitional Cell Bladder Carcinoma [O] . S. Lukacs, N. Szabo, S. Woodhams 2012

机译：罕见的抗HU抗体阳性坐癌性神经综合征和过渡性细胞膀胱癌协会
8. Virus-Specific Antibody-Producing Cells in Blood and Cerebrospinal Fluid in Acute Japanese Encephalitis [R] . Burke, D. S., Nisalak, A., Lorsomrudee, W., 1985

机译：急性日本脑炎患者血液和脑脊液中的病毒特异性抗体产生细胞

Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes

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