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首页> 外文期刊>Journal of natural products >Isoflavonoids and Coumarins from Glycyrrhiza uralensis: Antibacterial Activity against Oral Pathogens and Conversion of Isoflavans into Isoflavan-Quinones during Purification
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Isoflavonoids and Coumarins from Glycyrrhiza uralensis: Antibacterial Activity against Oral Pathogens and Conversion of Isoflavans into Isoflavan-Quinones during Purification

机译：甘草中的异黄酮和香豆素：对口腔病原菌的抗菌活性和纯化过程中异黄烷酮向异黄酮-喹诺酮类化合物的转化

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摘要

Phytochemical investigation of a supercritical fluid extract of Glycyrrhiza uralensis has led to the isolation of 20 known isoflavonoids and coumarins, and glycycarpan (7), a new pterocarpan. The presence of two isoflavan-quinones, licoriquinone A (8) and licoriquinone B (9), in a fraction subjected to gel filtration on Sephadex LH-20 is due to suspected metal-catalyzed oxidative degradation of licoricidin (1) and licorisoflavan A (2). The major compounds in the extract, as well as 8, were evaluated for their ability to inhibit the growth of several major oral pathogens. Compounds 1 and 2 showed the most potent antibacterial activities, causing a marked growth inhibition of the cariogenic species Streptococcus mutans and Streptococcus sobrinus at 10 mu g/mL and the periodontopathogenic species Porphyromonas gingivalis (at 5 mu g/mL) and Prevotella intermedia (at 5 mu g/mL for 1 and 2.5 mu g/mL for 2). Only 1 moderately inhibited growth of Fusobacterium nucleatum at the highest concentration tested (10 mu g/mL).
机译：对甘草超临界流体提取物的植物化学研究已导致分离出20种已知的异黄酮和香豆素，以及一种新的翼果聚糖glycycarpan（7）。在Sephadex LH-20上进行凝胶过滤的馏分中存在两种异黄酮醌，licoriquinone A（8）和licoriquinone B（9），这是由于怀疑的金属催化的licoricidin（1）和licorisoisoflavan A（ 2）。评价提取物中的主要化合物以及8种化合物抑制几种主要口腔病原体生长的能力。化合物1和2表现出最强的抗菌活性，致使致突变菌链霉菌和链霉菌链球菌的浓度分别为10μg/ mL和牙周病原菌齿龈卟啉单胞菌（浓度为5μg/ mL）和中间致病菌（浓度分别为5μg/ mL） 1克5克/毫升，2克2.5克/毫升。在最高测试浓度（10μg / mL）下，只有1种中度抑制了核梭菌的生长。

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