Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella.

Gunasekera SP; McCarthy PJ; Longley RE; Pomponi SA; Wright AE

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Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella.

机译：Secobatzellines A和B，来自Batzella属的一种深水加勒比海海绵的两种新的酶抑制剂。

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摘要

Secobatzelline A (1), a new batzelline natural analogue, and secobatzelline B (2), a likely artifact formed during the isolation procedure, have been isolated from a deep-water marine sponge of the genus Batzella. Secobatzellines A and B inhibited the phosphatase activity of calcineurin, and secobatzelline A inhibited the peptidase activity of CPP32. Both compounds showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of secobatzellines A (1) and B (2) are described.

机译：已经从Batzella属的深海海洋海绵中分离出新的batzelline天然类似物Secobatzellineline A（1）和在分离过程中可能形成的伪影secobatzelline B（2）。 Secobatzelline A和B抑制钙调神经磷酸酶的磷酸酶活性，而Secobatzelline A抑制CPP32的肽酶活性。两种化合物均显示出对P-388和A-549细胞系的细胞毒性。本文介绍了七bat鱼线A（1）和B（2）的分离和结构解析。

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来源
《Journal of natural products》 |1999年第8期|共4页
作者
Gunasekera SP; McCarthy PJ; Longley RE; Pomponi SA; Wright AE;
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正文语种 eng
中图分类中药学;生药学（天然药物学）;
关键词
Alkaloids; Porifera; Protease Inhibitors; Calcineurin; secobatzelline A; 生物碱类; 多孔动物门; 蛋白酶抑制药;

机译：Alkaloids;Porifera;Protease Inhibitors;Calcineurin;secobatzelline A;生物碱类;多孔动物门;蛋白酶抑制药;

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1. Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella. [J] . Gunasekera SP, McCarthy PJ, Longley RE, Journal of natural products . 1999,第8期

机译：Secobatzellines A和B，来自Batzella属的一种深水加勒比海海绵的两种新的酶抑制剂。
2. Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella. [J] . Gunasekera SP, McCarthy PJ, Longley RE, Journal of natural products . 1999,第1期

机译：Discorhabdin P，一种新的酶抑制剂，来自Batzella属的加勒比深海海绵。
3. Discorhabdins S, T, and U, new cytotoxic pyrroloiminoquinones from a deep-water Caribbean sponge of the genus Batzella [J] . Gunasekera SP, Zuleta IA, Longley RE, Journal of natural products . 2003,第12期

机译：Discorhabdins S，T和U，来自Batzella属深水加勒比海海绵的新的细胞毒性吡咯烷氨基醌
4. CHALLENGES IN THE PETROPHYSICAL AND DYNAMIC CHARACTERIZATION OF DEEP-WATER TURBIDITE DEPOSITS OF THE COLOMBIAN CARIBBEAN OFFSHORE â€“ A CASE STUDY. [C] . Juan Alejandro Angel Restrepo, Ricardo AndrÃ©s GÃ³mez-Moncada, Carlos Alberto Mora SÃ¡nchez, Society of Petrophysicists and Well Log Analysts, Inc.;SPWLA Annual Logging Symposium . 2020

机译：哥伦比亚加勒比海岸深水浊度沉积物岩石物理和动态特征的挑战 - 案例研究。
5. Chemical ecology of Caribbean sponges of the genus Aplysina. [D] . Puyana, Monica. 2001

机译：Aplysina属的加勒比海海绵的化学生态学。
6. Phylogenetic Diversity and Spatial Distribution of the Microbial Community Associated with the Caribbean Deep-water Sponge Polymastia cf. corticata by 16S rRNA aprA and amoA Gene Analysis [O] . Birte Meyer, Jan Kuever -1

机译：系统发育多样性和与加勒比海深水海绵polymastia相关的微生物群落的空间分布。通过16S rRNAaprA和amoa基因分析分析皮质
7. Phylogenetic Diversity and Spatial Distribution of the Microbial Community Associated with the Caribbean Deep-water Sponge Polymastia cf. corticata by 16S rRNA, aprA, and amoA Gene Analysis [O] . Birte Meyer, Jan Kuever 2008

机译：系统发育多样性和与加勒比海深水海绵polymastia相关的微生物群落的空间分布。通过16S rRNA，aprA和amoa基因分析分析皮质
8. Guide to the Deep-Water Sponges of the Aleutian Island Archipelago [R] . Stone, R. P., Lehnert, H., Reiswig, H. 2011

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Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella.

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