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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Fatty acid substituted polyvinyl alcohol as a supporting material for microsphere preparation
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Fatty acid substituted polyvinyl alcohol as a supporting material for microsphere preparation

机译：脂肪酸取代的聚乙烯醇作为微球制备的支撑材料

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摘要

Polyvinyl alcohol, substituted with lauric, myristic, palmitic, and stearic acids at different substitution degrees was employed for the preparation of bio-degradable microspheres containing progesterone or indomethacin. A solvent extraction/method was followed, starting from an oil-in-water dispersion containing the polymer and drug in the inner phase. Microspheres were obtained with high loading efficiency, whose release properties were dependent on the nature of the acyl substituent and the substitution degree. Kinetics approaching zero-order were obtained for the most hydrophile microspheres such as those based on thc least substituted polymers and lovvest moleerilar weight substituents. The hydrophilicity of these systems hindered protein absorption on their surface, suggesting their suitability for parenteral use.
机译：用不同取代度的月桂酸，肉豆蔻酸，棕榈酸和硬脂酸取代的聚乙烯醇用于制备含有孕酮或吲哚美辛的可生物降解的微球。从内相中包含聚合物和药物的水包油分散体开始，进行溶剂萃取/方法。获得了具有高负载效率的微球，其释放特性取决于酰基取代基的性质和取代度。对于大多数亲水性微球，例如基于最少取代的聚合物和最喜欢的分子量取代基的微球，动力学接近零级。这些系统的亲水性阻碍了蛋白质在其表面上的吸收，表明它们适合肠胃外使用。

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