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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Effect of adding non-volatile oil as a core material for the floating microspheres prepared by emulsion solvent diffusion method
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Effect of adding non-volatile oil as a core material for the floating microspheres prepared by emulsion solvent diffusion method

机译：乳液溶剂扩散法制备的漂浮微球中添加非挥发性油作为核心材料的效果

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dispersed phase. When an oil component was not miscible with water, over 90% was entrapped within the microspheres and prolonged the floating time of the microspheres. Depending on the solvent ratio, the morphologies of the microspheres were different and the best result was obtained when the ratio of dichloromethane:ethanol:isopropanol was 5:6:4. As the isopropanol portion increased, the time to form microspheres was delayed and the amount of fibre-like substance produced was decreased, due to the slow diffusion rate of the solvent. Compared with microspheres prepared without non-volatile oil, the release rate of the drug from microspheres was faster in all cases tested, except the microspheres containing mineral oil. The solubility of the drug in the non-volatile oil affected the release profiles of the drugs. The non-volatile oil tends to decrease the glass transition temperature of prepared microspheres and change the release profile. The internal morphology of the microspheres was slightly different depending on the entrapped oil phase used. Tiny spherical objects were present at the inner surface of microspheres and the inside of the shell.
机译：分散相。当油成分不能与水混溶时，超过90％的化合物会滞留在微球中，并延长微球的漂浮时间。取决于溶剂的比例，微球的形态不同，当二氯甲烷：乙醇：异丙醇的比例为5：6：4时，可获得最佳结果。随着异丙醇部分增加，由于溶剂的缓慢扩散速率，延迟了形成微球的时间并且减少了纤维状物质的产生量。与不含非挥发油的微球相比，在所有测试的情况下，药物从微球的释放速率都更快，但含有矿物油的微球除外。药物在非挥发性油中的溶解度影响药物的释放曲线。非挥发性油倾向于降低制备的微球的玻璃化转变温度并改变释放曲线。微球的内部形态根据所使用的截留油相而略有不同。在微球的内表面和壳内部存在微小的球形物体。

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