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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Biofriendly bonding processes for nanoporous implantable SU-8 microcapsules for encapsulated cell therapy
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Biofriendly bonding processes for nanoporous implantable SU-8 microcapsules for encapsulated cell therapy

机译：用于封装细胞疗法的纳米多孔可植入SU-8微胶囊的生物友好键合工艺

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摘要

Mechanically robust, cell encapsulating microdevices fabricated using photolithographic methods can lead to more efficient immunoisolation in comparison to cell encapsulating hydrogels. There is a need to develop adhesive bonding methods which can seal such microdevices under physiologically friendly conditions. We report the bonding of SU-8 based substrates through (i) magnetic self assembly, (ii) using medical grade photocured adhesive and (iii) moisture and photochemical cured polymerization. Magnetic self-assembly, carried out in biofriendly aqueous buffers, provides weak bonding not suitable for long term applications. Moisture cured bonding of covalently modified SU-8 substrates, based on silanol condensation, resulted in weak and inconsistent bonding. Photocured bonding using a medical grade adhesive and of acrylate modified substrates provided stable bonding. Of the methods evaluated, photocured adhesion provided the strongest and most stable adhesion.
机译：与使用细胞包封的水凝胶相比，使用光刻方法制造的机械坚固的细胞包封的微器件可导致更有效的免疫隔离。需要开发可以在生理上友好的条件下密封这种微型器件的粘合剂粘合方法。我们报告了通过（i）磁性自组装，（ii）使用医用级光固化胶粘剂和（iii）湿气和光化学固化聚合来粘合基于SU-8的基材。在生物友好型水性缓冲液中进行的磁性自组装提供了弱粘合力，不适合长期使用。基于硅烷醇缩合的共价改性SU-8基材的湿固化键合导致弱而不稳定的键合。使用医用级粘合剂和丙烯酸酯改性的基材进行光固化键合可提供稳定的键合。在评估的方法中，光固化粘合力提供最强和最稳定的粘合力。

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