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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >An overview of preparation and evaluation sustained-release injectable microspheres
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An overview of preparation and evaluation sustained-release injectable microspheres

机译：缓释可注射微球的制备和评估概述

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摘要

Recently, sustained-release injectable microspheres as a novel parenteral administration system have been interested on for many years, due to the excellent advantages when compared to traditional dosage forms: less administration frequency, lower adverse side effects and no need for a surgical procedure. Therefore, major progresses in the development of another successful marketed sustained-release injectable formation have been made, but most investigations are merely limited in laboratory levels; in addition, few reports focus on giving some positive guidance to launch these novel microspheres into market. This review addressed some commonly used polymers, preparation methods and sterilization processes relating to biodegradable microspheres. Moreover, the processes for measuring the sustained-release behaviour of this novel system are summarized in this report, including the methods to determine the in vitro and in vivo release behaviours and the strategies to analyse the in vitro and in vivo correlations.
机译：近年来，由于与传统剂型相比的优越性，缓释可注射微球作为新型肠胃外给药系统已引起人们的兴趣：给药频率更少，不良副作用更低且无需外科手术。因此，在开发另一种成功的市售缓释注射剂型方面取得了重大进展，但是大多数研究仅局限于实验室水平。此外，很少有报道集中精力为将这些新型微球推向市场提供积极指导。这篇综述涉及与生物可降解微球有关的一些常用聚合物，制备方法和灭菌方法。此外，本报告总结了测量该新型系统持续释放行为的过程，包括确定体外和体内释放行为的方法以及分析体外和体内相关性的策略。

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