...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >A new method for encapsulating hydrophobic compounds within cationic polymeric nanoparticles
【24h】

A new method for encapsulating hydrophobic compounds within cationic polymeric nanoparticles

机译：一种将疏水性化合物包裹在阳离子聚合物纳米粒子中的新方法

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Here we present the newly developed "solvent exchange" method that overcomes the challenge of encapsulating hydrophobic compounds within nanoparticle of water soluble polymers. Our studies involved the model polymer polyvinylpyrrolidone (PVP) and the hydrophobic dye Nile red. We found that the minimum molecular weight of the polymer required for nanoparticle formation was 49 KDa. Dynamic Light Scattering (DLS) and Cryo-Transmission Electron Microscopy (cryo-TEM) studies revealed spherical nanoparticles with an average diameter ranging from 20 to 33 nm. Encapsulation efficiency was evaluated using UV spectroscopy and found to be around 94%. The nanocarriers were found to be highly stable; less than 2% of Nile red release from nanoparticles after the addition of NaCI. Nanoparticles containing Nile red were able to penetrate into glioma cells. The solvent exchange method was proved to be applicable for other model hydrophobic drug molecules including ketoprofen, ibuprofen and indomethacin, as well as other solvents.
机译：在这里，我们介绍了最新开发的“溶剂交换”方法，该方法克服了将疏水性化合物包封在水溶性聚合物纳米颗粒中的挑战。我们的研究涉及模型聚合物聚乙烯吡咯烷酮（PVP）和疏水性染料尼罗红。我们发现纳米颗粒形成所需的聚合物的最小分子量为49 KDa。动态光散射（DLS）和低温透射电子显微镜（cryo-TEM）研究显示球形纳米颗粒的平均直径为20至33 nm。使用紫外光谱法评估封装效率，发现封装效率约为94％。发现纳米载体是高度稳定的。加入NaCl后，不到2％的尼罗红从纳米颗粒中释放出来。含有尼罗红的纳米颗粒能够穿透神经胶质瘤细胞。事实证明，该溶剂交换方法适用于其他模型疏水性药物分子，包括酮洛芬，布洛芬和消炎痛，以及其他溶剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号