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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Stability study of sodium colistimethate-loaded lipid nanoparticles
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Stability study of sodium colistimethate-loaded lipid nanoparticles

机译：载有大黄藻酸钠的脂质纳米颗粒的稳定性研究

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摘要

In the last decades, the encapsulation of antibiotics into nanoparticulate carriers has gained increasing attention for the treatment of infectious diseases. Sodium colistimethate-loaded solid lipid nanoparticles (Colist-SLNs) and nanostructured lipid carriers (Colist-NLCs) were designed aiming to treat the pulmonary infection associated to cystic fibrosis patients. The nanoparticles were freeze-dried using trehalose as cryoprotectant. The stability of both nanoparticles was analysed over one year according to the International Conference of Harmonisation (ICH) guidelines by determining the minimum inhibitory concentration (MIC) against clinically isolated Pseudomonas aeruginosa strains and by studying their physico-chemical characteristics. The results showed that Colist-SLNs lost their antimicrobial activity at the third month; on the contrary, the antibacterial activity of Colist-NLCs was maintained throughout the study within an adequate range (MIC <= 16 mu g/mL). In addition, Colist-NLCs exhibited suitable physico-chemical properties at 5 degrees C and 25 degrees C/60% relative humidity over one year. Altogether, Colist-NLCs proved to have better stability than Colist-SLNs.
机译：在过去的几十年中，将抗生素包封到纳米颗粒载体中对于治疗传染病越来越受到关注。设计了载有大黄藻酸钠的固体脂质纳米颗粒（Colist-SLNs）和纳米结构脂质载体（Colist-NLCs），旨在治疗与囊性纤维化患者相关的肺部感染。使用海藻糖作为冷冻保护剂将纳米颗粒冷冻干燥。根据国际协调会议（ICH）指南，通过确定临床分离的铜绿假单胞菌菌株的最低抑菌浓度（MIC）并研究其理化特性，分析了两种纳米颗粒的稳定性。结果表明，Colist-SLNs在第三个月就失去了抗菌活性。相反，在整个研究中，Colist-NLC的抗菌活性均保持在适当范围内（MIC <= 16μg / mL）。另外，Colist-NLC在一年中于5摄氏度和25摄氏度/ 60％相对湿度下表现出合适的理化特性。总的来说，Colist-NLC比Colist-SLN具有更好的稳定性。

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