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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Mucoadhesive controlled release microcapsules of indomethacin: Optimization and stability study
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Mucoadhesive controlled release microcapsules of indomethacin: Optimization and stability study

机译：吲哚美辛的粘膜粘附控释微胶囊：优化和稳定性研究

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摘要

The aim of this project was to develop and optimize indomethacin microcapsules composed of multiple mucoadhesive polymers for high drug entrapment, good mucoadhesiveness and drug release in a controlled fashion over a longer period of time. Microcapsules containing sodium alginate, sodium carboxy-methylcellulose, methylcellulose, Carbopol~R 934 and hydroxypropyl methylcellulose were prepared by orifice-ionic gelation method. The effects of composition of microcapsules on drug entrapment efficacy, drug release and mucoadhesive character were determined by mixture statistical design. Most formulations exhibited good mucoadhesive property in everted intestinal sac test. Drug entrapment efficiency (68-94%) was dependent on the type of polymers. Drug release (92-100%) extended over 12 h. The optimized formulation resulted in drug entrapment efficiency of 89.3%, drug release of 94.8% and mucoadhesiveness of 30.4%. All formulations were stable for more than 1.5 years. The optimized mucoadhesive microcapsules are promising for controlled delivery of indomethacin with twice a day oral administration.
机译：该项目的目的是开发和优化由多种粘膜粘附性聚合物组成的消炎痛微囊，以便在较长的时间内以可控的方式实现高药物截留，良好的粘膜粘附性和药物释放。通过孔板离子凝胶法制备了包含藻酸钠，羧甲基纤维素钠，甲基纤维素，Carbopol®R 934和羟丙基甲基纤维素的微胶囊。通过混合统计学设计确定了微胶囊的组成对药物包封效果，药物释放和粘膜粘附特性​​的影响。大多数配方在外翻肠囊测试中表现出良好的粘膜粘附特性​​。药物的包封率（68-94％）取决于聚合物的类型。药物释放（92-100％）持续12小时。优化的配方导致药物截留效率为89.3％，药物释放率为94.8％，粘膜粘附性为30.4％。所有配方均稳定超过1.5年。优化的粘膜粘附微胶囊有望通过每天两次口服来控制吲哚美辛的递送。

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