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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >The influence of stirring rae on biopharmaceutical properties of Eudragit RS microspheres
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The influence of stirring rae on biopharmaceutical properties of Eudragit RS microspheres

机译：搅拌rae对Eudragit RS微球生物药物性质的影响。

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摘要

Eudragit RS microspheres containing pipemidic acid, as a model drug, were prepared by the solvent evaporation method using an acetone/liquid paraffin solvent system. The aim of the work was to evaluate the influence of stirring rate on the average particle size, particle morphology, drug content and release kinetics, as well as the influence of particle size on microsphere morphology, drug content and release kinetics. Stirring rate has been found to significantly influence the average diameter of microspheres. The average diameter decreases as the stirring rate increases. This can be explained by production of a finer dispersion of droplets when higher stirring rates are applied and, consequently, by the formation of smaller microspheres. With increasing rate and increasing fraction particle size the drug content also increases. It is assumed that this dependence is a consequience of an uneven diffusion of the drug from the inner to the outer emulsion phase, and an uneven encapsulationof drug particles durg particles during the preparation. Drug release follows the Higuchi model. As seen from SEM photographs, larger microspheres are more porous and the microspheres produced at higher stirring rates are more porous than those produced at lower stirring rates. This explains the unexpected finding that the release rate increases as the fraction paarticle size and the stirring rate increase.
机译：使用丙酮/液体石蜡溶剂系统，通过溶剂蒸发法制备了含有哌啶酸作为模型药物的Eudragit RS微球。这项工作的目的是评估搅拌速度对平均粒径，颗粒形态，药物含量和释放动力学的影响，以及粒径对微球形态，药物含量和释放动力学的影响。已经发现搅拌速率显着影响微球的平均直径。随着搅拌速率的增加，平均直径减小。这可以通过在施加较高的搅拌速率时产生更细的液滴分散来解释，因此可以通过形成较小的微球来解释。随着速率的增加和级分粒度的增加，药物含量也增加。假定这种依赖性是由于药物从内乳剂相向外乳剂相的不均匀扩散以及在制备过程中药物颗粒的不均匀包封而引起的。药物的释放遵循Higuchi模型。从SEM照片可以看出，较大的微球比在较低搅拌速度下生产的微球更多孔，在较高搅拌速度下生产的微球更多孔。这解释了出乎意料的发现，即释放速率随部分颗粒尺寸和搅拌速率的增加而增加。

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