Vibrio cholerae-loaded poly(DL lactide co-glycolide) microparticles

M.-K. Yeh; J.-L. Chen; C.-H. Chiang

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Vibrio cholerae-loaded poly(DL lactide co-glycolide) microparticles

机译：霍乱弧菌负载的聚（DL丙交酯乙交酯）微粒

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Vibrio cholerae (VC)-loaded microparticles were prepared using poly(Dl lactide-co-glycoldie) with a wter-in-oil-in-water emulsion/solvent extraction technique. Particle characteristics including size distribution, VC-loading efficiencies, and in-vitro release pattern were investigated. The dispersed phase was PLG dissolved in dichloromethane, and the continuous phase was water containing PVP as a stabilizer with varied sodium chloride concentrations. VC was sucessfully entrapped in the microparticles with trapping efficiencies up to 97.8%, a loading level of 55.4 g/mg, and particle size of 3.8 #mu#m. Using 10% w/v PVP with 5% w/v NaCl in the contrinuous phase resulted in a higher loading level surface content (6.2+-0.9 g/mg) than without NaCl (loading content: 40.7+-5.1 g/mg; loading eficiency 52.1

机译：载有霍乱弧菌（VC）的微粒是使用聚（D1丙交酯-共-糖原）和水包油中的乳状液/溶剂萃取技术制备的。研究了颗粒特征，包括尺寸分布，VC加载效率和体外释放模式。分散相是PLG溶于二氯甲烷，连续相是含有PVP作为稳定剂的水，氯化钠浓度变化。 VC成功捕获在微粒中，捕集效率高达97.8％，装载量为55.4 g / mg，粒径为3.8＃μm。在连续相中使用10％w / v PVP和5％w / v NaCl会导致比没有NaCl时更高的负载水平表面含量（6.2 + -0.9 g / mg）（负载含量：40.7 + -5.1 g / mg;装载效率52.1

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《Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres》 |2002年第2期|共10页
作者
M.-K. Yeh; J.-L. Chen; C.-H. Chiang;
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正文语种 eng
中图分类药剂学;
关键词
Vibrio cholerae; biodegradable; microparticle4avaccination;

机译：霍乱弧菌;可生物降解;微粒4接种;

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1. Vibrio cholerae-loaded poly(DL lactide co-glycolide) microparticles [J] . M.-K. Yeh, J.-L. Chen, C.-H. Chiang Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres . 2002,第2期

机译：霍乱弧菌负载的聚（DL丙交酯乙交酯）微粒
2. The control of protein release from poly(DL-lactide co-glycolide) microparticles by variation of the external aqueous phase surfactant in the water-in oil-in water method [J] . Coombes AGA., Lavelle EC., Davis SS., Journal of Controlled Release: Official Journal of the Controlled Release Society . 1998,第3期

机译：水包油包水法中外部水相表面活性剂的变化控制聚（DL-丙交酯-乙交酯）微粒中蛋白质的释放
3. The distribution of protein associated with poly(DL-lactide co-glycolide) microparticles and its degradation in simulated body fluids [J] . Takahata H., Coombes AGA., Davis SS., Journal of Controlled Release: Official Journal of the Controlled Release Society . 1998,第1a3期

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4. THE CHARACTERISTIC OF Vibrio cholerae-LOADED PLGA MICROPARTICLES [C] . M.K. Yeh, J.L. Chen, C.H. Chiang International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：霍乱弧菌负载的PLGA微颗粒的特征
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6. Design of vitamin E d-α-Tocopheryl Polyethylene Glycol 1000 Succinate-Emulsified Poly (DL–Lactide–co-Glycolide) Nanoparticles: Influence of Duration of Ultrasonication Energy [O] . CT Şengel, C Hasçiçek, N Gönül 2011

机译：维生素Ed-α-生育酚聚乙二醇1000琥珀酸酯乳化的聚（DL-丙交酯-共乙醇酸内酯）纳米颗粒：超声能量持续时间的影响
7. Sodium alendronate loaded poly(l-lactide- co-glycolide) microparticles immobilized on ceramic scaffolds for local treatment of bone defects [O] . Łucja Rumian, Cornelia Wolf-Brandstetter, Sina Rößler, 2020

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Vibrio cholerae-loaded poly(DL lactide co-glycolide) microparticles

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