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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Characterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans
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Characterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans

机译：脂质体包裹的银离子对白色念珠菌的表征及体外抗菌潜力

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摘要

Liposomes are biocompatible, biodegradable, controlled delivery systems with the ability to encapsulate both lipophilic and hydrophilic compounds, including metal ions. Liposome encapsulated Ag+ (lipo-Ag+), prepared by reverse-phase evaporation, was used as a controlled delivery system against Candida albicans. Characterisation of the lipo-Ag+ indicated that the multilamellar vesicles with diameters ranging between approximate to 0.5 and 5.0 mu m showed potential as a controlled delivery system to consistently deliver Ag+ to C. albicans. Results from inductively coupled plasma (ICP) analysis showed higher association of cell bound Ag+ at 15 mins post exposure when compared to unencapsulated Ag+. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicate detrimental effects of Ag+ on C. albicans cell structure. These effects along with the ICP results also correlate with previously reported time kill experiment observations.
机译：脂质体是生物相容的，可生物降解的，受控的递送系统，具有包封亲脂性和亲水性化合物（包括金属离子）的能力。通过反相蒸发制备的脂质体包裹的Ag +（脂质-Ag +）被用作对抗白色念珠菌的控制传递系统。脂质-Ag +的表征表明，直径在约0.5-5.0μm之间的多层囊泡显示出作为可控的递送系统将Ag +持续递送至白色念珠菌的潜力。电感耦合等离子体（ICP）分析的结果表明，与未封装的Ag +相比，暴露后15分钟时细胞结合的Ag +具有更高的缔合力。扫描电子显微镜（SEM）和透射电子显微镜（TEM）表明Ag +对白色念珠菌细胞结构的有害影响。这些影响以及ICP结果也与先前报道的时间杀灭实验观察结果相关。

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