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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Effect of surfactant HLB and different formulation variables on the properties of poly-D,L-lactide microspheres of naltrexone prepared by double emulsion technique
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Effect of surfactant HLB and different formulation variables on the properties of poly-D,L-lactide microspheres of naltrexone prepared by double emulsion technique

机译：表面活性剂HLB和不同配方变量对双乳液法制备纳曲酮聚D，L-丙交酯微球性能的影响

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摘要

The aim of this work was to investigate the role of HLB of emulsifier as well as volume of the internal aqueous phase (W_1) and presence of salt in the external aqueous phase (W_2) on the morphology,size and encapsulation efficiency of poly(D,L-lactide) microspheres containing naltrexone HC1.PLA micro-particles containing naltrexone HC1,an effective opiate antagonist,were prepared by a water-in-oil-in-water emulsification-solvent evaporation procedure.One of the five different emulsifiers: span 80,span 20,tween 85,tween 80 and tween 20,with HLB values from 4-17 were added to W_1.Presence of emulsifier in W_1 resulted in smaller particles with a more dense and uniform internal structure.Incorporation of span 80 (HLB 4.3,suitable for W/O emulsions) yield the highest encapsulation efficiency.Increasing the HLB value to 8 or 11 (span 20 or tween 85) decreased the efficiency of naltrexone HCl-loading.HLB values higher than 15 (tween 80 or tween 20) increased encapsulation efficiency unexpectedly,which could be attributed to migration of these emulsifiers to the O/W_2 interface and modifying the surface properties of microparticles.Increasing the internal water phase volume from 0.2-1.8 ml resulted in larger particle size with poor encapsulation efficiency.Addition of 10% w/ w NaCl to the W_2 changed the surface morphology of microspheres from a porous form to a smooth surface.It was shown that,by selecting the appropriate HLB value of emulsifier in W_(15) addition of salt to W_2 and controlling the volume of W_(15) one can control the encapsulation efficiency,size and morphology of microspheres.
机译：这项工作的目的是调查乳化剂的HLB作用以及内部水相的体积（W_1）和外部水相中的盐（W_2）的存在对聚（D）的形态，尺寸和包封效率的影响（L-丙交酯）含纳曲酮HC1的微球。含纳曲酮HC1（有效的阿片拮抗剂）的PLA微粒是通过水包油包水型乳化溶剂蒸发法制备的。五种不同的乳化剂之一：将80，span 20，tween 85，tween 80和tween 20之间的HLB值从4-17添加到W_1中.W_1中存在乳化剂导致较小的颗粒具有更致密和均匀的内部结构.span 80（HLB）的引入4.3，适用于W / O乳剂）包封效率最高。将HLB值提高到8或11（量程20或吐温85）会降低纳曲酮HCl的装载效率.HLB值高于15（吐温80或吐温20） ）增加封装效率可能是由于这些乳化剂迁移到O / W_2界面并改变了微粒的表面性质。将内部水相体积从0.2-1.8 ml增加导致较大的粒径和较差的包封效率。添加量为10％ w / w NaCl到W_2将微球的表面形态从多孔形式改变为光滑表面。结果表明，通过在W_（15）向W_2添加盐的条件下选择合适的乳化剂HLB值并控制W_2的体积。 W_（15）可以控制微球的包封效率，大小和形态。

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