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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Treatment of adjuvant arthritis using microencapsulated antisense NF-κB oligonucleotides
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Treatment of adjuvant arthritis using microencapsulated antisense NF-κB oligonucleotides

机译：微囊化反义NF-κB寡核苷酸治疗佐剂性关节炎

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摘要

Antisense oligonucleotides are promising new therapeutic agents used to selectively inhibit target genes such as Nuclear Factor Kappa B (NF-κB), an important transcription factor in the pathogenesis of inflammatory disease. The purpose of the present study was to evaluate microencapsulated antisense oligonucleotides specific to NF-κB for in vitro efficacy and treatment of adjuvant-induced arthritis in rats. Oligonucleotide-loaded albumin microspheres were prepared and characterized in terms of size, zeta potential, morphology and release pattern. This study reports significant NF-κB inhibition in vitro after treatment with microencapsulated antisense oligonucleotides. Furthermore, microencapsulated anti-sense NF-κB oligonucleotides were found to inhibit paw inflammation associated with rat adjuvant-induced arthritis in a dose-dependent manner. Taken together, the results presented in this work described albumin microspheres to be effective delivery vehicles for antisense NF-κB oligonucleotides and a potential treatment for inflammatory diseases.
机译：反义寡核苷酸是有前途的新治疗剂，可用于选择性抑制靶基因，如核因子κB（NF-κB），这是炎症疾病发病机理中的重要转录因子。本研究的目的是评估对NF-κB特异的微囊化反义寡核苷酸在大鼠中的体外疗效和佐剂诱发的关节炎的治疗。制备了寡核苷酸负载的白蛋白微球，并根据大小，ζ电势，形态和释放模式对其进行了表征。这项研究报告了用微囊化的反义寡核苷酸治疗后，在体外对NF-κB有明显的抑制作用。此外，发现微囊化的反义NF-κB寡核苷酸以剂量依赖的方式抑制与大鼠佐剂诱导的关节炎有关的爪炎症。两者合计，这项工作中提出的结果描述了白蛋白微球是反义NF-κB寡核苷酸的有效传递载体和炎性疾病的潜在治疗方法。

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