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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Encapsulation of Vitamin A palmitate for animal supplementation: Formulation, manufacturing and stability implications
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Encapsulation of Vitamin A palmitate for animal supplementation: Formulation, manufacturing and stability implications

机译：维生素A棕榈酸酯封装用于动物补充：配方，制造和稳定性的影响

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摘要

Two manufacturing methods and numerous formulative approaches have been evaluated to obtain a stable oral pharmaceutical form of Vitamin A palmitate (VAP), a substance very sensitive to light, temperature, humidity and metal ions. The best results were obtained by formulating VAP, stabilized with butylated hydroxytoluene (BHT), in double layer microcapsules constituted by a core of chitosan, Tween 20, CaCl2 and EDTA surrounded by a first chitosan-alginate membrane and an outer membrane of calcium-alginate. This formulation design enabled the production of beads with high drug loading (42% w/w) and high encapsulation efficiency (94%). The stability of VAP-loaded microcapsules was assessed according to EMEA guidelines. This formulation design showed the best performance in terms of VAP recovery (t_(50%) > 360 days) after 1 year of storage at room conditions. This is a very important result considering the poor shelf-life (45 days) of pure VAP stabilized with BHT stored at the same conditions.
机译：已经评估了两种制造方法和多种配方方法，以获得稳定的口服药物形式的维生素A棕榈酸酯（VAP），该物质对光，温度，湿度和金属离子非常敏感。通过在由壳聚糖，吐温20，CaCl2和EDTA核心，被第一壳聚糖-海藻酸盐膜和海藻酸钙外膜包围的双层微胶囊中配制用丁基化羟基甲苯（BHT）稳定的VAP，可获得最佳结果。这种配方设计可以生产具有高载药量（42％w / w）和高包封效率（94％）的珠子。根据EMEA指南评估了加载VAP的微胶囊的稳定性。在室温下储存1年后，该制剂设计在VAP回收方面表现出最佳性能（t_（50％）> 360天）。考虑到在相同条件下用BHT稳定的纯VAP的保质期很短（45天），这是非常重要的结果。

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