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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Albumin nanoparticles with predictable size by desolvation procedure
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Albumin nanoparticles with predictable size by desolvation procedure

机译：去溶剂化工艺可预测大小的白蛋白纳米颗粒

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Nanoparticles prepared of human serum albumin (HSA) represent promising carriers for drug delivery. Desolvating procedure is a common method to obtain protein-based particles. However process parameters have a great influence on size, size distribution and particle yield of the resulting formulation. Therefore, it is crucial to investigate their effects on particle preparation. This study is focused on the influence of different desolvating agents on the resulting particle characteristics and cytotoxicity in cell culture. Another aspect of the study was the influence of different stirring rates, pre-stirring of the HSA solution and the continuous addition of desolvating agent during the preparation process. The results indicate that it is possible to predict the particle size depending on dielectric constant of the desolvation medium. Remarkably, combination of methanol and ethanol used as desolvating agent was able to produce very small spherical HSA nanoparticles in a size range between 50 and 80 nm.
机译：由人血清白蛋白（HSA）制备的纳米颗粒代表了有希望的药物递送载体。去溶剂化过程是获得基于蛋白质的颗粒的常用方法。然而，工艺参数对所得制剂的尺寸，尺寸分布和颗粒产率有很大的影响。因此，研究它们对颗粒制备的影响至关重要。这项研究的重点是不同去溶剂剂对细胞培养物中所产生的颗粒特征和细胞毒性的影响。研究的另一个方面是在制备过程中不同搅拌速率，预搅拌HSA溶液和连续添加去溶剂剂的影响。结果表明，可以根据去溶剂化介质的介电常数来预测粒径。值得注意的是，用作去溶剂剂的甲醇和乙醇的组合能够产生尺寸在50至80 nm之间的非常小的球形HSA纳米颗粒。

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