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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Formation of size-controlled nano carrier systems by self-assembly
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Formation of size-controlled nano carrier systems by self-assembly

机译：通过自组装形成尺寸受控的纳米载体系统

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摘要

Nano carrier systems were prepared by forming self-assembled liposomes having a size distribution in the nano range through use of an ultrasonic homogenizer. Phosphatidylcholine and cholesterol were utilized as an amphiphilic compound and a shape stabilizer, respectively. The size of prepared samples was decreased (up to 150nm) by elevating ratio of lecithin and extending homogenization time (2～6min). After secondary coating with alginic acid (0.1,0.3 and 0.5%,W/V), size was remarkably changed in the range of ±30 nm and zeta-potential was altered (only chitosan coating (molecular weight: 30 000 Da, 0.2%, W/V): 10.3mV, Alginic acid coating (0.5%, W/V) after the chitosan coating: - 21.8mV). The low molecular weight chitosan (0.1%,W/V)-coated nano-liposomes had a lower absolute value of zeta-potential than the high molecular weight chitosan (0.1%,W/V)-coated nano-liposomes. The encapsulation efficiency was measured by gas chromatography. The efficiency was decreased slightly by elevating chitosan concentration (0.1 ～ 0.5%,W/V).
机译：通过使用超声均化器形成尺寸分布在纳米范围内的自组装脂质体来制备纳米载体系统。磷脂酰胆碱和胆固醇分别用作两亲化合物和形状稳定剂。通过增加卵磷脂的比例和延长均质时间（2〜6min），可以减小制备样品的尺寸（最大150nm）。在用海藻酸（0.1、0.3和0.5％，W / V）进行二次涂层后，尺寸在±30 nm范围内发生了显着变化，并且改变了Zeta电位（仅使用壳聚糖涂层（分子量：30000 Da，0.2％） ，W / V）：10.3mV，壳聚糖涂层后的海藻酸涂层（0.5％，W / V）：-21.8mV）。与高分子量壳聚糖（0.1％，W / V）包覆的纳米脂质体相比，低分子量壳聚糖（0.1％，W / V）包覆的纳米脂质体具有更低的ζ电位绝对值。包封效率通过气相色谱法测定。通过提高壳聚糖浓度（0.1〜0.5％，W / V），效率略有下降。

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