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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >The intestinal permeation of didanosine from granules containing microspheres using the everted gut sac model
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The intestinal permeation of didanosine from granules containing microspheres using the everted gut sac model

机译：使用外翻肠囊模型从含微球的颗粒中透入二羟肌苷的肠渗透

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摘要

The aim of this research is to evaluate the intestinal permeation of a new formulation (NF) for the anti-retroviral didanosine (ddl) drug, using the everted gut sac model. The NF is composed by granules containing ddl incorporated in chitosan microspheres, plus free chitosan as an excipient. The permeation was evaluated across the three intestinal segments of adult male Wistar rats. The performance of ddl permeation from the NF was compared to the same granules without free chitosan and to buffered ddl tablets as control. The permeations across duodenum were higher than across jejune and ileum. The ddl from NF presented higher permeation and a crescent-shaped profile in duodenum compared to the other formulations. Such effects are provided by the superior mucoadhesiveness to the intestinal membrane and potentialize sustained release properties for NF. These results lead one to consider the novel formulation to be promising for ddl administration by oral route.
机译：这项研究的目的是使用翻倒的肠道囊模型评估一种抗逆转录病毒双羟肌苷（ddl）药物的新制剂（NF）的肠道渗透性。 NF由掺入壳聚糖微球中的含ddl的颗粒加上游离的壳聚糖作为赋形剂组成。在成年雄性Wistar大鼠的三个肠段中评估渗透率。将来自NF的ddl渗透的性能与不含游离壳聚糖的相同颗粒以及作为对照的缓冲ddl片剂进行了比较。十二指肠的渗透率高于空肠和回肠。与其他配方相比，NF中的ddl在十二指肠中表现出更高的渗透性和新月形轮廓。此类作用是通过对肠膜的优异粘膜粘附性提供的，并具有潜在的NF持续释放特性。这些结果导致人们认为该新型制剂有望通过口服途径给予ddl。

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