• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L.): Characterization of aqueous dispersions and lyophilized formulations
【24h】

Liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L.): Characterization of aqueous dispersions and lyophilized formulations

机译：掺入巴西樱桃精油（Eugenia uniflora L.）的脂质体：水分散液和冻干制剂的表征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Multilamellar liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L) leaves were produced by dry film hydration. Gas chromatography demonstrated the compounds found in the essential oil were effectively incorporated in the aqueous dispersions of liposomes. Differential scanning calorimetry analyses revealed the incorporation of the essential oil did not cause phase separation in the membrane structure; the gel-liquid crystalline transition temperature (main transition) remained the same despite the higher heterogeneity indicated by the transition peak broadening. Different cryoprotectors (sucrose and trehalose) were added to the liposomal formulations to be tested in their ability to protect the liposomal structure during the lyophilization. The morphological aspect of the lyophilized powders analysed by scanning electron microscopy showed significant differences among the samples with and without cryoprotectors. Fourier-transform infrared spectroscopy indicated the cryoprotectors interacted effectively with the polar heads of phospholipids in the bilayer. In terms of water absorption, trehalose was identified as a much more effective protector agent against it than sucrose. The cryoprotectors showed different degrees of effectiveness of preservation of the liposomal structure when the rehydration assays of lyophilized liposomes were carried out, as particle size measurements indicated a moderate process of fusion when the formulations with sucrose were rehydrated.
机译：通过干膜水合作用制备了掺入巴西樱桃（Eugenia uniflora L）叶精油的多层脂质体。气相色谱法证明在香精油中发现的化合物有效地掺入脂质体的水分散体中。差示扫描量热分析表明，香精油的掺入并没有引起膜结构的相分离。尽管过渡峰变宽表明较高的非均质性，但凝胶-液晶的转变温度（主转变）保持不变。将不同的冷冻保护剂（蔗糖和海藻糖）添加到脂质体制剂中，以测试它们在冻干过程中保护脂质体结构的能力。通过扫描电子显微镜分析的冻干粉末的形态方面显示在具有和不具有防冻剂的样品之间存在显着差异。傅里叶变换红外光谱表明，低温保护剂与双层中磷脂的极性头有效相互作用。就吸水性而言，海藻糖被认为是比蔗糖更有效的保护剂。当进行冻干脂质体的再水化分析时，冷冻保护剂显示出脂质体结构保存的不同程度的有效性，因为当蔗糖制剂重新水化时，粒度测量表明融合过程中等。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号