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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Perfluorocarbon-filled poly(lactide-co-gylcolide) nano- and microcapsules as artificial oxygen carriers for blood substitutes: a physico-chemical assessment
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Perfluorocarbon-filled poly(lactide-co-gylcolide) nano- and microcapsules as artificial oxygen carriers for blood substitutes: a physico-chemical assessment

机译：全氟化碳填充的聚（丙交酯-共-乙交酯）纳米胶囊和微胶囊作为血液替代品的人造氧气载体：物理化学评估

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摘要

The physico-chemical suitability of perfluorocarbon-filled capsules as artificial oxygen carriers for blood substitutes is assessed on the example of biodegradable poly(lactide-co-gylcolide) micro- and nanocapsules with a liquid content of perfluorodecalin. The morphology of the capsules is studied by confocal laser scanning microscopy using Nile red as a fluorescent marker. The mechanical stability and the wall flexibility of the capsules are examined by atomic force microscopy. The permeability of the capsule walls in connection with the oxygen uptake is detected by nuclear magnetic resonance. It is shown that the preparation in fact leads to nanocapsules with a mechanical stability which compares well with the one of red blood cells. The capsule walls exhibit sufficient permeability to allow for the exchange of oxygen in aqueous environment. In the fully saturated state, the amount of oxygen dissolved within the encapsulated perfluorodecalin in aqueous dispersion is as large as for bulk perfluorodecalin. Simple kinetic studies are presently restricted to the time scale of minutes, but so far indicate that the permeability of the capsule walls could be sufficient to allow for rapid gas exchange.
机译：以具有全氟萘烷液体含量的可生物降解的聚（丙交酯-共-gylcolide）微胶囊和纳米胶囊为例，评估了全氟化碳填充的胶囊作为血液替代品的人造氧气载体的理化适应性。通过使用尼罗红作为荧光标记的共聚焦激光扫描显微镜研究了胶囊的形态。通过原子力显微镜检查胶囊的机械稳定性和壁柔性。通过核磁共振检测与氧气吸收有关的囊壁的渗透性。结果表明，该制剂实际上导致具有机械稳定性的纳米胶囊，该纳米胶囊与红细胞之一相比具有很好的稳定性。胶囊壁表现出足够的渗透性以允许在水性环境中交换氧气。在完全饱和状态下，溶解在水分散液中的包封的全氟萘烷中的氧的量与本体全氟萘烷一样大。目前，简单的动力学研究仅限于分钟的时间范围，但到目前为止，表明胶囊壁的渗透性足以允许快速的气体交换。

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