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首页> 外文期刊>Journal of nephrology. >Renal failure is a risk factor for cefepime-induced encephalopathy.
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Renal failure is a risk factor for cefepime-induced encephalopathy.

机译：肾功能衰竭是头孢吡肟引起的脑病的危险因素。

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BACKGROUND: Cefepime is a widely used antibiotic. However, it can cause encephalopathy, which has been increasingly described in the literature, occurring mainly in patients with impaired renal function. The primary objective in this study was to measure the incidence of cefepime-induced encephalopathy and determine potential risk factors for its occurrence. METHODS: In the period from February 2005 to February 2006, a prospective cohort study was conducted, which followed 498 patients using cefepime. Other metabolic problems were ruled out for all patients with clinical suspicion of encephalopathy and, when cefepime was the probable cause, electroencephalographic (EEG) tests were performed to assist in the diagnosis, with the first performed during cefepime use and another performed at least 48 hours following drug discontinuation and/or clinical improvement. RESULTS: Among patients selected for this study (n=498), 5 were diagnosed with cefepime-induced encephalopathy, thus indicating a cumulative incidence of approximately 1% (0.01), 387 had glomerular filtration rate (GFR) >or=60 ml/min and 111 had GFR <60 ml/min. Among the latter, 5 patients developed cefepime-induced encephalopathy. Mean GFR value in patients with encephalopathy (n=5) was 17.20 ml/min (SD +/-10.75 ml/min) and, in patients without encephalopathy (n=106) it was 32.59 ml/min (SD +/-14.89 ml/min) (p=0.025). CONCLUSION: The development of cefepime-induced encephalopathy seems to be related to the severity of impairment in glomerular filtration.
机译：背景：头孢吡肟是一种广泛使用的抗生素。但是，它会引起脑病，这在文献中已有越来越多的描述，主要发生在肾功能受损的患者中。这项研究的主要目的是测量头孢吡肟诱发的脑病的发生率，并确定其发生的潜在危险因素。方法：在2005年2月至2006年2月期间，进行了一项前瞻性队列研究，随访了498例头孢吡肟患者。排除了所有临床怀疑脑病的患者的其他代谢问题，当头孢吡肟是可能的病因时，进行了脑电图（EEG）检查以帮助诊断，第一次使用头孢吡肟期间进行，另一次进行至少48小时停药和/或临床改善后。结果：本研究选择的患者（n = 498）中，有5名被诊断为头孢吡肟诱发的脑病，因此表明累积发生率约为1％（0.01），其中387的肾小球滤过率（GFR）≥60 ml / min和111的GFR ＜60ml / min。在后者中，有5名患者发生了头孢吡肟诱发的脑病。脑病患者（n = 5）的平均GFR值为17.20 ml / min（SD +/- 10.75 ml / min），无脑病患者（n = 106）的GFR平均值为32.59 ml / min（SD +/- 14.89） ml / min）（p = 0.025）。结论：头孢吡肟引起的脑病的发展似乎与肾小球滤过功能障碍的严重程度有关。

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