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首页> 外文期刊>Journal of nephrology. >Metabolic syndrome and chronic kidney disease in high-risk Italian hypertensive patients: the I-DEMAND study.
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Metabolic syndrome and chronic kidney disease in high-risk Italian hypertensive patients: the I-DEMAND study.

机译：高危意大利高血压患者的代谢综合征和慢性肾脏疾病：I-DEMAND研究。

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Metabolic syndrome (MS) and chronic kidney disease (CKD) are well-known, independent predictors of increased cardiovascular risk. Both conditions are fairly prevalent in the general population. The aim of this study was to assess the relationship between MS or its individual components and CKD in an Italian population of hypertensive patients with normal or mildly to moderately impaired renal function under specialist care.A total of 2,916 patients (mean age 62 ± 11 years) among those enrolled in the I-DEMAND study were taken into consideration for this analysis. MS was defined according to the NCEP-ATP III criteria. CKD was defined as an estimated GFR (abbreviated MDRD equation) <60 ml/min/1.73m2 or as the presence of microalbuminuria (mean albumin-to-creatinine ratio =2.5 mg/mmol in men and =3.5 mg/mmol in women).MS was present in 59% of our study patients. The prevalence of microalbuminuria, reduced GFR and CKD was 26%, 25%, and 41%, respectively. Patients with MS had higher urinary albumin excretion (p<0.0001), lower GFR (p=0.0077), and a greater prevalence of CKD (p<0.0001), even after adjusting for age and gender. Multivariate logistic regression analysis revealed that MS was significantly associated with CKD, even after adjusting for several potential confounders including its individual components (OR 1.33, 95%CI 1.03-1.71, p=0.0268). The association between MS and CKD was stronger in nondiabetic patients.Renal abnormalities and MS are frequently associated in hypertensive patients under specialist care. This relationship is independent of several potential confounding factors including the components of MS.
机译：代谢综合症（MS）和慢性肾脏病（CKD）是心血管风险增加的众所周知的独立预测因子。这两种情况在普通人群中相当普遍。这项研究的目的是评估在专科护理下在正常或轻度至中度肾功能受损的意大利高血压患者人群中MS或其单个成分与CKD的关系。总共2,916名患者（平均年龄62±11岁） ）参加I-DEMAND研究的人被纳入此分析。 MS是根据NCEP-ATP III标准定义的。 CKD定义为估计的GFR（缩写为MDRD方程）<60 ml / min / 1.73m2或存在微量白蛋白尿（男性的平均白蛋白与肌酐之比= 2.5 mg / mmol，女性= 3.5 mg / mmol）在我们研究的患者中，有59％存在MS。微量白蛋白尿，降低的GFR和CKD的患病率分别为26％，25％和41％。 MS患者即使调整了年龄和性别，其尿白蛋白排泄量较高（p <0.0001），GFR较低（p = 0.0077）和CKD患病率较高（p <0.0001）。多元逻辑回归分析表明，即使在调整了包括其单个成分在内的几个潜在混杂因素之后，MS与CKD仍显着相关（OR 1.33，95％CI 1.03-1.71，p = 0.0268）。在非糖尿病患者中MS与CKD之间的关联更强，在专科护理下的高血压患者中肾脏异常与MS经常相关。这种关系独立于几个潜在的混淆因素，包括MS的组成部分。

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