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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Novel dithranol phospholipid microemulsion for topical application: development, characterization and percutaneous absorption studies
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Novel dithranol phospholipid microemulsion for topical application: development, characterization and percutaneous absorption studies

机译：用于局部应用的新型二乙醇醇磷脂微乳剂：开发，表征和经皮吸收研究

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摘要

The objective of this study was to develop and characterize a novel dithranol-containing phospholipid microemulsion systems for enhanced skin permeation and retention. Based on the solubility of dithranol, the selected oils were isopropyl myristate (IPM) and tocopherol acetate (TA), and the surfactants were Tween 80 (T80) and Tween 20 (T20). The ratios of cosurfactants comprising of phospholipids and ethanol (1:10) and surfactant to co-surfactant (1:1 and 2.75:1) were fixed for the phase diagram construction. Selected microemulsions were evaluated for globule size, zeta potential, viscosity, refractive index, per cent transmittance, stability (freeze thaw and centrifugation), ex vivo skin permeation and retention. The microemulsion systems composed of 1PM and T80 with mean particle diameter of 72.8 nm showed maximum skin permeation (82.23%), skin permeation flux (0.281 mg/cm~2/h) along with skin retention (8.31%) vis-a-vis systems containing TA and T20. The results suggest that the developed novel lecithinized microemulsion systems have a promising potential for the improved topical delivery of dithranol.
机译：这项研究的目的是开发和表征新型的含二乙醇醇的磷脂微乳体系，以增强皮肤的渗透性和保留性。基于二乙醇的溶解度，选择的油是肉豆蔻酸异丙酯（IPM）和生育酚乙酸酯（TA），表面活性剂是吐温80（T80）和吐温20（T20）。固定相图时，应确定由磷脂和乙醇组成的辅助表面活性剂（1:10）和表面活性剂与辅助表面活性剂的比率（1：1和2.75：1）。评估所选微乳剂的小球尺寸，ζ电位，粘度，折射率，透光率，稳定性（冻融和离心），离体皮肤渗透和保留。由1PM和T80组成的平均粒径为72.8 nm的微乳液体系显示最大皮肤渗透率（82.23％），皮肤渗透通量（0.281 mg / cm〜2 / h）和相对于皮肤的保留率（8.31％）包含TA和T20的系统。结果表明，已开发的新型卵磷脂微乳化系统具有改善二乙醇烷的局部递送的有希望的潜力。

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