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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Cellular uptake of Nigella sativa oil-PLGA microparticle by PC-12 cell line
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Cellular uptake of Nigella sativa oil-PLGA microparticle by PC-12 cell line

机译：PC-12细胞系对黑质木油-PLGA微粒的细胞吸收

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摘要

The aim of this study is to investigate the cell uptake of Nigella sativa oil (NSO)-PLGA microparticle by neuron-like PC-12 cells in comparison to surfactants; hydrophilic (Tween 80 & Triton X100) and hydrophobic (Span 80). Solvent evaporation was used to precisely control the size, zeta potential and morphology of the particle. The results revealed varying efficiencies of the cell uptake by PC-12 cells, which may be partially attributed to the surface hydrophobicity of the microparticles. Interestingly, the uptake efficiency of PC-12 cells was higher with the more hydrophilic microparticle. NSO microparticle showed evidence of being preferably internalised by mitotic cells. Tween 80 microparticle showed the highest cell uptake efficiency with a concentration-dependent pattern suggesting its use as uptake enhancer for non-scavenging cells. In conclusion, PC-12 cells can take up NSO-PLGA microparticle which may have potential in the treatment of neurodegenerative disease.
机译：这项研究的目的是研究与表面活性剂相比，神经元样PC-12细胞对Nigella sativa oil（NSO）-PLGA微粒的细胞吸收。亲水性（Tween 80＆Triton X100）和疏水性（Span 80）。使用溶剂蒸发来精确控制颗粒的大小，ζ电势和形态。结果表明PC-12细胞吸收细胞的效率各不相同，这可能部分归因于微粒的表面疏水性。有趣的是，亲水性微粒使PC-12细胞的吸收效率更高。 NSO微粒显示出优选被有丝分裂细胞内化的证据。 Tween 80微粒显示出最高的细胞吸收效率，且具有浓度依赖性模式，表明其可用作非清除细胞的吸收增强剂。总之，PC-12细胞可以吸收NSO-PLGA微粒，该微粒可能在神经退行性疾病的治疗中具有潜力。

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