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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Dextran-based hydrogel microspheres obtained in w/o emulsion: preparation, characterisation and in vivo studies
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Dextran-based hydrogel microspheres obtained in w/o emulsion: preparation, characterisation and in vivo studies

机译：不使用乳液获得的基于葡聚糖的水凝胶微球：制备，表征和体内研究

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摘要

The cross-linking reaction in w/o emulsions of dextran (DEX) functionalised with methacrylic groups, having or not acid residues in side chain, can be used to easily prepare polysaccharide hydrogel microspheres with properties suitable for drug delivery applications. The formation of a chemical network within the obtained particles was evaluated with FT-IR spectroscopy, whereas morphology and dimensions of the microspheres were investigated with optical and scanning electron microscopy. At the same time, swelling measurements were carried out on freeze-dried particles in different aqueous media simulating biological fluids. Preliminary release experiments performed with ibuprofen, betamethasone and vitamin B12 chosen as model drugs, showed that these microspheres could be suitable as modified drug delivery systems in oral formulations. Finally, in vivo writhing experiments were carried out in mice in order to verify the antinociceptive activity of betamethasone loaded into the new polysaccharide hydrogel microspheres.
机译：在具有甲基丙烯酸基团官能化的右旋糖酐（DEX）的无水乳液中，在侧链中具有或不具有酸残基的交联反应可用于轻松制备具有适合药物输送应用特性的多糖水凝胶微球。用FT-IR光谱法评价所得颗粒内化学网络的形成，而用光学和扫描电子显微镜研究微球的形态和尺寸。同时，在模拟生物流体的不同水性介质中，对冻干的颗粒进行了溶胀测量。使用布洛芬，倍他米松和维生素B12作为模型药物进行的初步释放实验表明，这些微球可能适合用作口服制剂中的改良药物递送系统。最后，在小鼠体内进行了扭体实验，以验证加载到新的多糖水凝胶微球中的倍他米松的镇痛活性。

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