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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Influence of surfactants,polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model
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Influence of surfactants,polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model

机译：表面活性剂，聚合物和阿霉素负载量对大鼠神经胶质瘤模型中聚氰基丙烯酸丁酯纳米颗粒抗肿瘤作用的影响

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摘要

Poly(n-butyl cyanoacrylate) nanoparticles coated with polysorbate-80 can enable the transport of bound drugs across the blood-brain barrier (BBB) after i.v.injection.In the present study the influence of different formulation parameters on the anti-tumoural effects of doxorubicin nanoparticles against glioblastoma 101/8 was investigated.The manufacturing parameters of poly(alkyl cyanoacrylate) doxorubicin-loaded nanoparticles were optimized concerning drug loading.The nanoparticles were coated with different surfactants and injected intravenously on days 2,5 and 8 after intra-cranial implantation of glioblastoma 101/8 to rats.The survival times of all doxorubicin containing preparations,including a doxorubicin solution,increased the survival times significantly compared to untreated tumour-bearing rats.The most pronounced increase in survival was obtained with the poly(n-butyl cyanoacrylate) doxorubicin-loaded nanoparticles coated with polysorbate 80 and 35% of these animals survived for over 180 days (termination of the experiments).The other nanoparticle preparations yielded lower survival times.Poly(n-butyl cyanoacrylate) doxorubicin-loaded nanoparticles coated with polysorbate 80-coated proved to be very efficient against glioblastoma 101/8.The data suggest that the interaction of nanoparticles with the blood after injection as well as the enhanced permeability and retention effect (EPR effect) contributed differently to the anti-tumoural efficacy depending on nanoparticle formulation and surface properties.
机译：聚山梨酯80包覆的聚氰基丙烯酸正丁酯纳米粒子可以使结合的药物在静脉注射后穿过血脑屏障（BBB）转运。研究了针对阿胶质母细胞瘤101/8的阿霉素纳米颗粒。优化了载有聚氰基丙烯酸烷基酯的阿霉素纳米颗粒的制备参数，优化了载药量。在颅内注射后第2,5和8天将纳米颗粒涂有不同的表面活性剂并静脉内注射将成胶质细胞瘤101/8植入大鼠体内。与未治疗的荷瘤大鼠相比，所有含阿霉素制剂（包括阿霉素溶液）的存活时间均显着增加了存活时间.poly（n-负载聚山梨酸酯的载有阿霉素的纳米颗粒负载氰基丙烯酸丁酯80％，其中35％的动物存活了或超过180天（实验终止）。其他纳米颗粒制剂的存活时间更短。负载聚山梨酯80的聚（氰基丙烯酸正丁酯）负载阿霉素的纳米颗粒对胶质母细胞瘤101/8非常有效。提示注射后纳米颗粒与血液的相互作用以及增强的通透性和保留作用（EPR效应）取决于纳米颗粒的配方和表面性质对抗肿瘤功效的贡献不同。

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