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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Characterization and in vitro degradation of salicylate-derived poly(anhydride-ester microspheres)
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Characterization and in vitro degradation of salicylate-derived poly(anhydride-ester microspheres)

机译：水杨酸酯衍生的聚（酸酐酯微球）的表征和体外降解

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The aim of this study was to investigate how glass transition temperature (T_g) influenced polymer microsphere formation and degradation of three chemically, similar novel salicylate-based poly(anhydride-esters): poly[1,6-bis(o-carboxyphenoxy)hexanoate] (CPH), T_g=59 deg C; poly[1,8-bis(o-carboxyphenoxy)octanoate] (CPO), T_g = 30 deg C; and poly[1,10-bis(ocarboxyphenoxy) decanoate] (CPD), T_g=27 deg C. Microspheres of these polymers were prepared using a modified oil-in-water solvent evaporation method and processed by either resuspension or washed by centrifugation. The morphology of the microspheres determined by scanning electron microscopy (SEM) revealed that an extra washing step appears to increase aggregation as the T_g decreases; whereas only limited aggregation occurred in the polymer with the lowest T_g, CPD, in those not washed by centrifugation. Residual polyvinyl alcohol apparently affected the drug release rates from the microspheres by a stabilization process that produced an 8 h lag time and a 5% decrease in the amount of drug released over a 7 day period compared to microspheres washed free of PVA. These results demonstrate that salicylate-based poly(anhydride-esters) with sufficiently high T_gs, can be processed into microspheres that release salicylate over a time period amenable for drug delivery applications.
机译：这项研究的目的是调查玻璃化转变温度（T_g）如何影响聚合物微球的形成和降解，这三种化学上相似的基于水杨酸酯的新型聚（酸酐酯）：聚[1,6-双（邻-羧基苯氧基）己酸]（CPH），T_g = 59摄氏度;聚[1，8-双（邻-羧基苯氧基）辛酸酯]（CPO），T_g ＝ 30℃;和聚[1,10-双（邻羧基苯氧基）癸酸酯]（CPD），T_g = 27℃。使用改进的水包油溶剂蒸发法制备这些聚合物的微球，并通过重悬浮或离心洗涤进行处理。通过扫描电子显微镜（SEM）测定的微球的形态表明，随着T_g的降低，额外的洗涤步骤似乎会增加聚集。而没有离心分离的聚合物中，T_g CPD最低的聚合物仅发生有限的聚集。残留的聚乙烯醇通过稳定过程明显地影响了微球的药物释放速率，与无PVA洗涤的微球相比，该稳定过程产生了8小时的滞后时间，并且在7天的时间内释放的药物量减少了5％。这些结果表明，具有足够高的T_gs的基于水杨酸酯的聚（酸酐-酯）可以被加工成微球，其在适合药物递送应用的时间段内释放出水杨酸酯。

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